The effects of the cutaneous application of EMLA cream (a eutectic mixture of lignocaine and prilocaine in their base form) were studied in volunteers. When tested by pin-prick, EMLA cream 2.5% and 5% produced analgesia of the area tested, the cream being most effective if left in contact with the skin for 60 min. The pain produced by the insertion of an i.v. cannula was successfully blocked by the application of this formulation, especially if applied to the antecubital area. Temporary blanching of the skin areas was frequently observed on removal of the occlusive tape bandages, but prolonged, or repeated, application of 5% EMLA cream did not produce local skin reactions. Tests for delayed hypersensitivity reactions were negative. Plasma concentrations of lignocaine and prilocaine were low after a standard application.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/bja/57.10.997 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of vapocoolant spray compared to eutectic lidocaine/prilocaine cream to enhance tolerance during intravenous catheterisation: a randomised controlled trial.
J Small Anim Pract
January 2025
Department of Clinical Science and Services, The Royal Veterinary College, University of London, Hatfield, UK.
Objectives: To determine if tolerance of intravenous catheterisation differs following the application of vapocoolant spray compared to lidocaine/prilocaine cream in dogs and cats.
Materials And Methods: A randomised controlled trial of client-owned dogs and cats requiring intravenous catheterisation was performed. They were randomly allocated to either have lidocaine/prilocaine cream applied to their skin 1 hour prior to intravenous catheterisation or a swab saturated with vapocoolant spray applied immediately prior to intravenous catheterisation.
Local Lidocaine-Prilocaine for Immunisation in Infants.
Vaccines (Basel)
November 2024
Third Pediatric Discipline, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, 400124 Cluj-Napoca, Romania.
: Lidocaine-prilocaine cream effectively reduces vaccination pain, improving vaccination adherence and advocating for its routine use in healthcare settings. : This review used PRISMA guidelines and the PICOT format to structure the analysis. The focus was on paediatric patients aged 0-12 months requiring intramuscular vaccinations, comparing the application of lidocaine-prilocaine cream to other interventions or no treatment.
View Article and Find Full Text PDFComparison of Different Local Anesthetics in Cervical Facet Medial Branch Blockade.
World Neurosurg
January 2025
Ankara University Faculty of Medicine, Department of Anesthesia and Intensive Care, Ankara University Ibni Sina Hospital, Ankara, Turkey.
Objective: Cervical medial branch blocks (CMBBs) are frequently used for the treatment of facet arthropathy. The present study compares the effectiveness of lidocaine and prilocaine in CMBB procedures.
Methods: Patients with facet arthropathy scheduled for CMBB were randomly divided into 2 groups who were administered a combination of 2 mg dexamethasone and either 1% lidocaine or 1% prilocaine with a total volume of 1 mL per level.
Efficacy of 4% tetracaine gel and lidocaine-prilocaine cream in reducing local anesthetic injection pain in upper eyelid blepharoplasty: a randomized, single-blinded, controlled trial.
BMC Ophthalmol
December 2024
Department of Ophthalmology, The Second Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Background: The injection of local anesthetics, an extremely painful procedure, leads to a reduction of patients' acceptance.
Objective: To investigate the efficacy and adverse reactions of 4% tetracaine gel (TG) and lidocaine-prilocaine cream (LPC) on reducing the local anesthetic injection pain for upper eyelid blepharoplasty.
Methods: Sixty participants were equally divided into three groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!