A 3-yr follow-up study on the trend of memory performance in 9 elderly subjects with selective memory defects, which was carried out in an attempt to clarify the evolution of the disorder, revealed marked worsening of sensory visual memory, retention capacity and recent memory. No other mental function was compromised. The results of this study suggest that the onset of a selective memory defect in the elderly is not necessarily the expression of a demential amnestic syndrome, but rather the manifestation of a senile brain deterioration limited to the anatomo-functional memory system.
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http://dx.doi.org/10.1016/0167-4943(85)90023-8 | DOI Listing |
J Clin Oncol
January 2025
Center for Cell Engineering, Sloan Kettering Institute, New York, NY.
Purpose: We designed a CD19-targeted chimeric antigen receptor (CAR) comprising a calibrated signaling module, termed 1XX, that differs from that of conventional CD28/CD3ζ and 4-1BB/CD3ζ CARs. Preclinical data demonstrated that 1XX CARs generated potent effector function without undermining T-cell persistence. We hypothesized that 1XX CAR T cells may be effective at low doses and elicit minimal toxicities.
View Article and Find Full Text PDFFront Psychiatry
January 2025
Department of General Internal Medicine and Psychosomatics, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany.
Background: Previous research has indicated cognitive impairments in patients with post-traumatic stress disorder (PTSD), specifically in attention, memory, and executive functioning. However, there is limited knowledge about the cognitive profile of individuals with complex PTSD (cPTSD), a new diagnosis in ICD-11. Moreover, predictors of cognitive impairment remain unclear.
View Article and Find Full Text PDFBrain Behav Immun Health
December 2024
Justus-Liebig University Giessen, Germany.
Functional cognition is relevant for athletic success and interdependent with physical exercise, yet despite repeatedly demonstrated inflammatory responses to physical training, there are no studies addressing the relationship between cognition and inflammation in athletes. The aim of this study was to investigate the relationship between cognitive performance and selected inflammatory, and further physiological biomarkers in elite athletes. Data from 350 elite athletes regarding cognitive performance (processing speed, selective attention, working memory, cognitive flexibility), systemic inflammatory markers, metabolic hormones, growth factors, tissue damage markers, and micronutrients (e.
View Article and Find Full Text PDFFront Vet Sci
January 2025
College of Life Science, Longyan University, Longyan, China.
Trained immunity, characterized by long-term functional reprogramming of innate immune cells, offers promising new directions for veterinary vaccine development. This perspective examines how trained immunity can be integrated into veterinary vaccine design through metabolic reprogramming and epigenetic modifications. We analyze key molecular mechanisms, including the shift to aerobic glycolysis and sustained epigenetic changes, that enable enhanced immune responses.
View Article and Find Full Text PDFJMIR Med Inform
January 2025
Fundación INTRAS, Valladolid, Spain.
Background: This review explores the potential of virtual reality (VR) and artificial intelligence (AI) to identify preclinical cognitive markers of Alzheimer disease (AD). By synthesizing recent studies, it aims to advance early diagnostic methods to detect AD before significant symptoms occur.
Objective: Research emphasizes the significance of early detection in AD during the preclinical phase, which does not involve cognitive impairment but nevertheless requires reliable biomarkers.
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