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Acute hemolytic crisis complicated with ischemic cardiac injury and methemoglobinaemia following ingestion of naphthalene: a case report.
J Med Case Rep
December 2024
Faculty of Healthcare Sciences, Eastern University of Sri Lanka, Chenkaladi, Sri Lanka.
Background: Naphthalene is an aromatic hydrocarbon that potentially produces methemoglobinaemia but rarely causes hemolysis, especially in children with underlying glucose-6-phosphate dehydrogenase deficiency. Although ingestion of a single moth ball by an older child may not be life threatening, it can be fatal if ingested by a toddler.
Case Presentation: A 2-year-old Singhalese boy developed acute severe hemolysis and methemoglobinaemia following ingestion of a mothball.
Evidence of a Catalytic Dyad in F-Dependent Glucose-6-phosphate Dehydrogenase from .
Biochemistry
January 2025
Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019-0065, United States.
F-dependent glucose-6-phosphate dehydrogenase (FGD) catalyzes the conversion of glucose-6-phosphate (G6P) to 6-phosphogluconolactone, using cofactor F as the hydride transfer acceptor. Our previous pH dependence studies suggested that E109 serves as an active site acid, donating a proton to the N-1 position of F, while leaving the role of H40 unanswered, which was previously suggested to serve as the active site base. This work utilizes thermodynamic and kinetic studies to elucidate additional mechanistic details concerning the roles of H40 and E13.
View Article and Find Full Text PDFPentose phosphate pathway of glucose-6-phosphate oxidation in the liver of rats with alloxan diabetes on the background of melatonin administrations and variable photoperiod.
Pol Merkur Lekarski
December 2024
BUKOVYNIAN STATE MEDICAL UNIVERSITY, CHERNIVTSI, UKRAINE.
Objective: . Aim: To find out the influence of melatonin on the enzyme activities of glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and transketolase in the liver of rats with alloxan diabetes under conditions of variable photoperiod.
Patients And Methods: Materials and Methods: Experiments were conducted on male outbred white rats weighing 180±10 mg.
Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis.
Int J Mol Sci
November 2024
Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy that affects approximately 500 million people worldwide. A great number of mutations in the gene have been described. However, three class A G6PD variants known as G6PD Tomah (C385R), G6PD Kangnam (C385G), and G6PD Madrid (C385W) have been reported to be clinically important due to their associations with severe clinical manifestations such as hemolytic anemia.
View Article and Find Full Text PDFRising epidemiological trends in prevalence and mortality of mpox: Global insights and analysis.
Saudi Med J
December 2024
From the College of Medicine (MOS Meo, MZS Meo, Khan), Alfaisal University; from the Department of Family Medicine (Butt) and Department of Physiology (S. Meo), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Objectives: To explore the global epidemiological trends in the prevalence and mortality due to mpox in various regions worldwide.
Methods: In this cross-sectional study the data about mpox outbreak were recorded by the "World Health Organization, Centers for Disease Control and Prevention, and GSAID" from August 2023 to August 2024, analyzing the epidemiological trends from different countries worldwide.
Results: The total number of mpox cases has reached 99,518 (95,196 cases from 115 countries that have not historically reported mpox; and 4,322 cases from 07 states that have traditionally reported mpox), from a total of 122 countries.
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