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Blood plasma proteomic markers of Alzheimer's disease, current status and application prospects.
Expert Rev Proteomics
January 2025
Skolkovo Institute of Science and Technology, Moscow, Russian Federation.
Introduction: Identifying early risks of developing Alzheimer's disease (AD) is a major challenge as the number of patients with AD steadily increases and requires innovative solutions. Current molecular diagnostic modalities, such as cerebrospinal fluid (CSF) testing and positron emission tomography (PET) imaging, exhibit limitations in their applicability for large-scale screening. In recent years, there has been a marked shift toward the development of blood plasma-based diagnostic tests, which offer a more accessible and clinically viable alternative for widespread use.
View Article and Find Full Text PDFAnchorage Accurately Assembles Anchor-Flanked Synthetic Long Reads.
Lebniz Int Proc Inform
August 2024
Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA Department of Computer Science and Engineering, The Pennsylvania State University, University Park, PA, USA.
Modern sequencing technologies allow for the addition of short-sequence tags, known as anchors, to both ends of a captured molecule. Anchors are useful in assembling the full-length sequence of a captured molecule as they can be used to accurately determine the endpoints. One representative of such anchor-enabled technology is LoopSeq Solo, a synthetic long read (SLR) sequencing protocol.
View Article and Find Full Text PDFA cross-sectional survey of farmer reported prevalence and farm management practices associated with neonatal infectious arthritis ("joint ill") in lambs, on UK sheep farms.
Front Vet Sci
December 2024
Department of Livestock and One Health, Institute of Infection, Veterinary and Ecologica Science, University of Liverpool, Neston, United Kingdom.
Introduction: Neonatal infectious arthritis (NIA) is a bacterial disease of lambs in the first month of life. NIA is associated with poor animal welfare, economic losses, and prophylactic antibiotic use. Farmers report problems with NIA despite following current guidance on prevention.
View Article and Find Full Text PDFCross-Cultural Validity and Reliability of the Thai Version of the Simple Shoulder Test.
Orthop J Sports Med
January 2025
Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Background: The Simple Shoulder Test (SST) is a widely used patient-reported outcome measure for shoulder function. However, there is currently no version of the SST for the Thai population.
Purpose: To cross-culturally adapt and evaluate the reliability and validity of a Thai version of the SST (Thai SST) for patients with shoulder pathologies, using the Thai version of the American Shoulder and Elbow Surgeons (ASES) score as a comparison tool.
Photoexcited Electro-Driven Reactive Oxygen Species Channeling for Precise Extraction of Biomarker Information from Tumor Interstitial Fluid.
Small
January 2025
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing, 400044, China.
Direct electrochemical detection of miRNA biomarkers in tumor tissue interstitial fluid (TIF) holds great promise for adjuvant therapy for tumors in the perioperative period, yet is limited by background interference and weak signal. Herein, a wash-free and separation-free miRNA biosensor based on photoexcited electro-driven reactive oxygen channeling analysis (LEOCA) is developed to solve the high-fidelity detection in physiological samples. In the presence of miRNA, nanoacceptors (ultrasmall-size polydopamine, uPDA) are responsively assembled on the surface of nanodonors (zirconium metal-organic framework, ZrMOF) to form core-satellite aggregates.
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