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Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.
J Cell Mol Med
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Hepatobiliary Center, the First Affiliated Hospital of Nanjing Medical University & Research Unit of Liver Transplantation and Transplant Immunology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
The global incidence of biliary tract cancer (BTC) is on the rise, presenting a substantial healthcare challenge. The integration of immune checkpoint inhibitors (ICIs) with molecularly targeted therapies is emerging as a strategy to enhance immune responses. However, the efficacy and underlying mechanisms of these treatments in BTC are still largely unexplored.
View Article and Find Full Text PDFLigand-to-Ligand Charge Transfer Induced Red-Shifted Room Temperature Phosphorescence in Metal-Organic Frameworks.
J Am Chem Soc
March 2025
Department of Chemistry, and the Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, PR China.
Research on room temperature phosphorescence (RTP) of metal-organic frameworks (MOFs) has been rapidly developed in recent years. However, it is still challenging to realize long-wavelength RTP (>580 nm). In this article, a new strategy is proposed to achieve the red-shifted RTP through constructing dual-ligand MOFs.
View Article and Find Full Text PDFMechanistic Insight into the Photoinduced Decarboxylative Radical Addition of Carboxylic Acid to Alkenes in a Two-Molecule Photoredox System.
J Org Chem
March 2025
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan.
The detailed mechanism of photoinduced decarboxylative radical addition to alkenes using both the effect of an electron donor (ED)/electron acceptor (EA) and laser flash photolysis in a two-molecule photoredox system was investigated. The concentration of EA played an important role in the photoreaction and could be controlled by varying the concentrations of ED/EA and their identity, which influenced Δ. Higher concentrations of ED/EA and a larger negative Δ led to a higher concentration of EA, thereby increasing the yield of the adduct; however, the large negative Δ for the generation of the EDA complex hindered decarboxylation.
View Article and Find Full Text PDFPhosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins.
J Am Chem Soc
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Institute of Biological Chemistry, Academia Sinica, No. 128, Sec. 2, Academia Road, Nankang, Taipei 115, Taiwan.
In this study, the role of phosphorylation in the liquid-liquid phase separation (LLPS) of tau, the underlying driving forces, and the potential implications of this separation on protein conformation and subsequent protein aggregation were investigated. We compared in vivo-produced phosphorylated tau (p-tau) and nonphosphorylated tau under different coacervation conditions without adding crowding agents. Our findings revealed that spontaneous phase separation occurs exclusively in p-tau, triggered by a temperature shift from 4 °C to room temperature, and is driven by electrostatic and hydrophobic interactions.
View Article and Find Full Text PDFSulfur traits in the plant microbiome: implications for sustainable agriculture.
Trends Microbiol
March 2025
Singapore Centre for Environmental Life Sciences Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore; NUS Environmental Research Institute, National University of Singapore, Singapore 117411, Singapore. Electronic address:
Owing to its biochemical flexibility, sulfur (S) is uniquely poised to fulfill versatile roles in plant-microbe interactions - impacting their metabolism with significant consequences for plant health and the global S cycle. We present evidence that the diversity of S-metabolic genes in plant-associated microbiomes (phytobiomes) is underappreciated, and plant niches are hotspots of bacterial S-metabolism with implications for S emissions. Building upon emerging findings, we posit that coordination of S-metabolism between plants and phytobiomes is a common mechanism for plant-microbe homeostasis and agriculturally beneficial microbial services.
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