Using present-day techniques, we measured the activity of pancreatic lipase in the serum and duodenal juice, the activity of monoglyceride lipase in the duodenal juice, the concentration of lipoproteins in the bile, the activity of intestinal enzymes (monoglyceride lipase and alkaline phosphatase) and the concentration of lipid fractions in the feces. These parameters were determined in six test subjects who were exposed to head-down tilt (-4.5 degrees) for 120 days. Our findings suggest that bed rest decreases lipolytic enzymes in the duodenal juice and increases pancreatic lipase in the serum. The exposure also leads to a decrease of the lipoproteins in the bile, rearrangement of the lipolytic enzymes in the intestine, and to an increase of mono-, di- and triglycerides in the feces. Our results are indicative of changes in the pancreatic function and in lipid hydrolysis and absorption. They can be interpreted as compensatory-adaptive processes of the digestive organs.
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