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Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
Allergol Select
October 2024
Center for Child and Adolescent Health, Helios Hospital Krefeld, Academic Hospital of RWTH Aachen, Krefeld.
Article Synopsis
- Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
- Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
- Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
[Eosinophilic granulomatosis with polyangiitis: a review article].
Laryngorhinootologie
October 2024
Klinik für Rheumatologie und Klinische Immunologie, Department Innere Medizin, Universitätsklinikum Freiburg, Freiburg, Germany.
Article Synopsis
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease that affects small blood vessels and causes inflammation, usually with allergic symptoms like asthma and sinus issues.
- It can lead to serious problems in different parts of the body, including the lungs, heart, and skin, and sometimes makes it hard to tell apart from another illness called hypereosinophilic syndrome (HES).
- Treatments for EGPA depend on how severe it is, with stronger medicines like glucocorticoids often used for serious cases, and other options available for less severe cases.
A case report of refractory multivessel coronary spasm associated with hypereosinophilic syndrome: one cell, one disease?
Eur Heart J Case Rep
May 2024
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574 Sendai, Japan.
Article Synopsis
- Hypereosinophilic syndrome (HES) involves high eosinophil levels, excluding other causes, and can lead to serious organ damage, including affecting coronary arteries and causing vasospastic angina (VSA).
- A 55-year-old woman with allergies and chest pain was found to have VSA due to spasms in her coronary arteries, with moderate eosinophilia during tests leading to a diagnosis of HES alongside eosinophilic pneumonia and chronic rhinosinusitis.
- Treatment with corticosteroids rapidly alleviated her symptoms and reduced eosinophil counts, highlighting the efficacy of this therapy for addressing both the VSA and underlying HES.
Case report: Probable toxocariasis in a Swiss adult patient with hypereosinophilic syndrome and multiorgan involvement.
SAGE Open Med Case Rep
September 2023
Department of Internal Medicine, Hospital of Thun, Thun, Switzerland.
Hypereosinophilic syndromes are a heterogeneous group of rare diseases characterized by eosinophil-related organ damage and peripheral blood hypereosinophilia. Hypereosinophilic syndromes may occur secondary to a variety of clinical entities, for example, drug hypersensitivity reactions, parasitic infections, autoimmune disorders, and malignancies. Toxocariasis is a parasitic infection caused by the larval stage of the species.
View Article and Find Full Text PDFDevelopment of eosinophilic pneumonia from eosinophilic bronchiolitis without asthma: A case report.
Respir Med Case Rep
July 2023
Department of Pulmonary Medicine and Oncology, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan.
Eosinophilic bronchiolitis is a disease concept reported in Japan in 2001, that presents with bronchiolitis accompanied by eosinophilia in the blood and lungs. In 2013, hypereosinophilic obliterative bronchiolitis, as a group of disease presenting with eosinophilic bronchiolitis, was proposed in France. The relationship between eosinophilic bronchiolitis and other eosinophil-related diseases has not been clarified.
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