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Correlation of zero echo time functional MRI with neuronal activity in rats.
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A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Zero echo time (zero-TE) pulse sequences provide a quiet and artifact-free alternative to conventional functional magnetic resonance imaging (fMRI) pulse sequences. The fast readouts (<1 ms) utilized in zero-TE fMRI produce an image contrast with negligible contributions from blood oxygenation level-dependent (BOLD) mechanisms, yet the zero-TE contrast is highly sensitive to brain function. However, the precise relationship between the zero-TE contrast and neuronal activity has not been determined.
View Article and Find Full Text PDFSemiparametric estimator for the covariate-specific receiver operating characteristic curve.
Stat Methods Med Res
January 2025
CITMAga and Department of Statistics and Operations Research, Universidade de Vigo, Vigo, Galicia, Spain.
The study of the predictive ability of a marker is mainly based on the accuracy measures provided by the so-called confusion matrix. Besides, the area under the receiver operating characteristic curve has become a popular index for summarizing the overall accuracy of a marker. However, the nature of the relationship between the marker and the outcome, and the role that potential confounders play in this relationship could be fundamental in order to extrapolate the observed results.
View Article and Find Full Text PDFMulticategory matched learning for estimating optimal individualized treatment rules in observational studies with application to a hepatocellular carcinoma study.
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School of Mathematics, Sun Yat-sen University, Guangzhou, Guangdong, China.
One primary goal of precision medicine is to estimate the individualized treatment rules that optimize patients' health outcomes based on individual characteristics. Health studies with multiple treatments are commonly seen in practice. However, most existing individualized treatment rule estimation methods were developed for the studies with binary treatments.
View Article and Find Full Text PDFImmunotherapy-based neoadjuvant treatment and complication rates after radical cystectomy.
BJU Int
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Urology Department, Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA.
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Methods: A bi-centre analysis was conducted in patients who underwent RARC with intracorporeal urinary diversion and who received an immunotherapy-based neoadjuvant regimen between 2017 and 2023. Complications were classified using the Clavien-Dindo system.
Anonymize or synthesize? Privacy-preserving methods for heart failure score analytics.
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Klaus Tschira Institute for Integrative Computational Cardiology, University Hospital Heidelberg, Im Neuenheimer Feld 669, 69120 Heidelberg, Germany.
Aims: Data availability remains a critical challenge in modern, data-driven medical research. Due to the sensitive nature of patient health records, they are rightfully subject to stringent privacy protection measures. One way to overcome these restrictions is to preserve patient privacy by using anonymization and synthetization strategies.
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