Progressive degradation in the appearance of digital plethysmogram tracings occurs during acute episodes of occlusive arteriopathies, and is of importance for establishing the diagnosis and the choice of therapy. The distal microvasculotissular score is of major interest during the stages defined by R. Fontaine in 1966. Changes are in fact those of rheologic factors in the terminal network. It is logical to incriminate variations in "tone" and of vasomotor response, the final relay being at the site distal to the circulatory units and their endothelial receptors. The problem should be envisaged at each stage in the course of the disease. Vasoplasticity is a function of the severity of the arteriopathy.
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J Headache Pain
February 2024
School of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St, Taipei, Taiwan.
Background: The pathophysiology of the reversible cerebral vasoconstriction syndrome (RCVS) remains enigmatic and the role of glymphatics in RCVS pathophysiology has not been evaluated. We aimed to investigate RCVS glymphatic dynamics and its clinical correlates.
Methods: We prospectively evaluated the glymphatic function in RCVS patients, with RCVS subjects and healthy controls (HCs) recruited between August 2020 and November 2023, by calculating diffusion-tensor imaging along the perivascular space (DTI-ALPS) index under a 3-T MRI.
Brain Sci
December 2023
Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Bruxelles, Belgium.
Background: Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme expressed in different cells of the central nervous system (CNS) and involved in the regulation of cerebral blood flow (CBF). The aim of this review was to understand the effects of acetazolamide on CBF, intracranial pressure (ICP) and brain tissue oxygenation (PbtO) after an acute brain injury (ABI).
Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA), we performed a comprehensive, computer-based, literature research on the PubMed platform to identify studies that have reported the effects on CBF, ICP, or PbtO of acetazolamide administered either for therapeutic or diagnostic purposes in patients with subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain injury, and hypoxic-ischemic encephalopathy.
Innov Pharm
October 2023
College of Pharmacy, University of Minnesota, Minneapolis, MN.
Rev Med Liege
May 2023
Service de Médecine physique et Réadaptation fonctionnelle, CHU Liège, Belgique.
Complex regional pain syndrome is a clinical entity that usually occurs following trauma, surgery, or other triggering event. Patients complain of pain described as burning, associated with sensory, vasomotor, sudomotor, motor and/or trophic disorders. The pain appears disproportionate to the initial lesion.
View Article and Find Full Text PDFAtherosclerosis
February 2021
Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Electronic address:
Background And Aims: The value of serial coronary artery calcium (CAC) scores to predict changes in absolute myocardial perfusion and epicardial vasomotor function is poorly documented. This study explored the association between progression of CAC score and changes in absolute myocardial perfusion.
Methods: Fifty-three patients (26% female) with de novo single-vessel coronary artery disease underwent [O]HO positron emission tomography/computed tomography at 1 month (baseline), 1 year, and 3 years after complete revascularization with percutaneous coronary intervention (PCI) to assess CAC scores, hyperemic myocardial blood flow (hMBF), coronary flow reserve (CFR) and cold pressor test MBF (CPT-MBF), within the context of the VANISH trial.
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