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Factors associated with Onchocerca volvulus transmission after 20 years of community treatment with ivermectin in savanah and forest areas in Central African Republic: A Cross Sectional Study.
PLoS Negl Trop Dis
December 2024
Department of Public Health, Faculty of Health Sciences, University of Bangui, Central African Republic.
The Central African Republic has endemic onchocerciasis in 20 health districts in savannah and forest areas. The country organised a mass distribution campaign of invermectin in 2023 through the National Onchocerciasis Control Programme. The objectives of this study were to identify factors of persistent Onchocerca volvulus transmission.
View Article and Find Full Text PDFMorphological description and genetic analysis of a new black fly species (Diptera: Simuliidae) in the subgenus Asiosimulium from central Thailand.
Parasit Vectors
September 2024
Parasitology and Entomology Research Cluster (PERC), Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Article Synopsis
- A new black fly species named Simulium (Asiosimulium) kittipati sp. nov. has been identified from central Thailand, which is noteworthy due to its potential role in transmitting Onchocerca volvulus, a significant parasite.
- The identification involved collecting black fly larvae and pupae, allowing adult flies to emerge, and then analyzing their morphology and molecular data, specifically the COI gene, to establish their classification.
- Key distinguishing features of the new species include specific anatomical traits in females and males, unique characteristics in pupae and larvae, along with a clear genetic divergence from related species, confirming its status as a new member of the Asiosimulium subgenus.
Identification and Characterization of Heat Shock Protein 70 (HSP70) as Novel Diagnostic Marker of Onchocerciasis in Human Urine.
Pathogens
March 2024
Laboratory for Molecular Parasitology, Department of Microbiology and Parasitology, University of Buea, Buea P.O. Box 63, Cameroon.
Despite several decades of mass drug administration and elimination-related activities, human onchocerciasis still represents a major parasitic threat in endemic regions. Among the challenges encountered by the elimination program is the lack of a suitable diagnostic tool that is accurate and non-invasive. Currently used methods are either invasive or not suitable for monitoring large numbers of patients.
View Article and Find Full Text PDFDifferential susceptibility of Onchocerca ochengi adult male worms to flubendazole in gerbils and hamsters.
Parasitol Res
April 2024
ANDI Centre of Excellence for Onchocerciasis Drug Research, Biotechnology Unit, Faculty of Science, University of Buea, Buea, Cameroon.
Onchocerciasis is a devastating skin and eye disease that afflicts about 21 million people, most of whom live in sub-Saharan Africa. Its control with the microfilaricidal drug ivermectin is limited, thus necessitating the development of preclinical animal models to aid in the discovery of a macrofilaricide. Previously, we found that Onchocerca ochengi (the closest relative of the human O.
View Article and Find Full Text PDFEpilepsy and nodding syndrome in association with an Onchocerca volvulus infection drive distinct immune profile patterns.
PLoS Negl Trop Dis
August 2023
Center for Global Health, School of Medicine, Technical University of Munich, Munich, Germany.
Previous studies have described the association of onchocerciasis (caused by Onchocerca volvulus) with epilepsy, including nodding syndrome, although a clear etiological link is still missing. Cases are found in different African countries (Tanzania, South Sudan, Uganda, Democratic Republic of the Congo, Central African Republic and Cameroon). In our study we investigated immunological parameters (cytokine, chemokine, immunoglobulin levels) in individuals from the Mahenge area, Tanzania, presenting with either epilepsy or nodding syndrome with or without O.
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