An hospital survey, performed in Bamako (Mali, West Africa) showed 7.5% haemoglobin AC, 0.4% haemoglobin CC, 1.6% haemoglobin SC and 0.2% haemoglobin CA (haemoglobin C-beta+thalassaemia). Haemoglobin C was mostly prevalent among Bobo, Mossi, Senoufo, Minianka and Dogon coming from the Southern border of Mali. Haemoglobin SC and to a lesser extent haemoglobins CC and CA often induce haemolysis and vasoocclusion. Microcytosis is common, even in the absence of anaemia.
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Alzheimers Dement
December 2024
Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China;, Beijing, China.
Background: Individuals with type 2 diabetes mellitus (T2DM) face an increased risk of dementia. Recent discoveries indicate that SGLT2 inhibitors, a newer class of anti-diabetic medication, exhibit beneficial metabolic effects beyond glucose control, offering a potential avenue for mitigating the risk of Alzheimer's disease (AD). However, limited evidence exists regarding whether the use of SGLT2 inhibitors effectively reduces the risk of AD.
View Article and Find Full Text PDFAsian Cardiovasc Thorac Ann
January 2025
Departments of Cardiac Surgery, HMC, Doha, Qatar.
Bombay blood (hh blood) is a rare blood group (4 per million), with no expression of the H antigen present in blood group O. Bombay blood patients can only receive Bombay blood, with autodonation used for elective surgery. We present a Bombay patient (haemoglobin 12.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Background: India is unfortunately the "Diabetes Capital" of the world with estimated 101 million and 136 million patients suffering from diabetes and prediabetes respectively. Prediabetes is a transition state between euglycemia and diabetes. Although diabetes is associated with cognitive decline, studies that link prediabetes and cognition have been scarce and inconclusive especially from the Low and Middle Income (LMIC) countries.
View Article and Find Full Text PDFActa Chir Orthop Traumatol Cech
January 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Kütahya Health Sciences University, Kütahya, Turkey.
Purpose Of The Study: Cognitive disorders are common in geriatric surgical patients We conducted a study to evaluate depression and cognitive behavior in geriatric patients undergoing orthopedic surgery.
Material And Methods: This descriptive cross-sectional study was conducted at a university hospital in Turkey, involving 262 elderly patients who underwent orthopedic surgeries. Data were collected using The Patient Information Form, Standardized Mini-Mental Test, and Geriatric Depression Scale.
Haematologica
January 2025
Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati OH; University of Cincinnati College of Medicine, Cincinnati OH; Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati OH.
Over the past 40 years, the introduction and refinement of hydroxyurea therapy has led to remarkable progress for the care of individuals with sickle cell anemia (SCA). From initial small proof-of-principle studies to multi-center Phase 3 controlled clinical trials and then numerous open-label studies, the consistent benefits of once-daily oral hydroxyurea have been demonstrated across the lifespan. Elevated fetal hemoglobin (HbF) serves as the most important treatment response, as HbF delays sickle hemoglobin polymerization and reduces erythrocyte sickling.
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