57 infertile couples with "unknown" or "therapy resistant" infertility were investigated by the double crossed sperm-penetration-meter-test (SPM-test). The results of the SPM-test were compared with the results of the postcoital-tests, the duration of infertility, and the male and female diagnosis of infertility. Postcoital tests and SPM-tests showed only in 63% of cases corresponding results. The ability of the spermatozoa to penetrate cervical mucus was directly depending from the number of progressively motile spermatozoa per ml, and no connection could be found between the results of the SPM-test and the gynecological findings. The investigations showed that the primary diagnosis of infertility can be extended by the SPM-test respectively in many cases of so-called "unknown infertility" where a disturbed spermatozoa-mucus-interaction has to be postulated.
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