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Identification of biological significance of different stages of varicose vein development based on mRNA sequencing.
Sci Rep
September 2024
Department of Vascular Surgery, Shaanxi Provincial People's Hospital, No.256 Youyi west Road, Xi'an, 710068, Shaanxi, China.
Article Synopsis
- A study looked at how normal veins can become varicose (VV) and possibly lead to blood clots (SVT) by using samples and special tests to find important genes involved in these changes.
- They found six key genes that might help explain how VV progresses or gets better, especially focusing on a gene called DACT3, which seems to stop VV from getting worse.
- The research suggests a drug called Cimetidine could help treat VV and SVT, and the findings can help understand how the immune system is involved in these vein problems.
Use of a Double-Transfected System to Predict hOCT2/hMATE1-Mediated Renal Drug-Drug Interactions.
Drug Metab Dispos
March 2024
Department of Pharmaceutics, University of Washington, Seattle, Washington
Accurate predictions of renal drug-drug interactions (DDIs) mediated by the human organic cation transporter 2 (hOCT2) and multidrug and toxin extrusion proteins (hMATEs) remain challenging. Current DDI evaluation using plasma maximal unbound inhibitor concentrations (I) and IC values determined in single transporter-transfected cells frequently leads to false or overprediction especially for hMATE1. Emerging evidence suggests intracellular unbound inhibitor concentration may be more relevant for hMATE1 inhibition in vivo.
View Article and Find Full Text PDFIdentification and characterization of an endogenous biomarker of the renal vectorial transport (OCT2-MATE1).
Biopharm Drug Dispos
February 2024
The First Clinical Medical School, Lanzhou University, Lanzhou, China.
The renal tubular organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the vectorial elimination of many drugs and toxins from the kidney, and endogenous biomarkers for vectorial transport (OCT2-MATE1) would allow more accurate drug dosing and help to characterize drug-drug interactions and toxicity. Human serum uptake in OCT2-overexpressing cells and metabolomics analysis were carried out. Potential biomarkers were verified in vitro and in vivo.
View Article and Find Full Text PDFCimetidine for recurrent respiratory papillomatosis in pregnancy as an alternative adjuvant treatment.
Eur Arch Otorhinolaryngol
February 2024
Department of Otolaryngology, Faculty of Medicine, University Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia.
Background: We report the first case of cimetidine as an alternative adjuvant therapy in a pregnant woman with recurrent respiratory papillomatosis (RRP). A 40 year old woman at 19 week gestation presented with progressive hoarseness and shortness of breath for 1 month. Flexible nasopharyngolaryngoscopy revealed multiple papillomatous lesions over both vocal cords and subglottic area obstructing 60% of her airway.
View Article and Find Full Text PDFInfluence of Topography and Composition of Commercial Titanium Dental Implants on Cell Adhesion of Human Gingiva-Derived Mesenchymal Stem Cells: An In Vitro Study.
Int J Mol Sci
November 2023
Laboratory of Nanobiomaterials, Research Institute of Dental Sciences, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.
Article Synopsis
- The study examines how the surface topography and composition of dental implants affect mesenchymal cell functions essential for osseointegration, specifically focusing on cell adhesion, proliferation, and differentiation.
- Various commercial titanium implants with different surface treatments were characterized, comparing sandblasted/acid-etched and calcium phosphate treatments, while a smooth surface served as a control.
- Results indicated that the Biounite implant, featuring a regular topography and calcium phosphate treatment, had superior protein adsorption and mesenchymal stem cell adhesion compared to other implants tested.
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