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Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice.
Nat Commun
January 2025
The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York, USA.
The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. A small subset of vagal sensory neurons innervate the liver and project centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver.
View Article and Find Full Text PDFMechanosensation of the heart and gut elicits hypometabolism and vigilance in mice.
Nat Metab
January 2025
Neuroscience Institute, College of Arts and Sciences, Georgia State University, Atlanta, GA, USA.
Interoception broadly refers to awareness of one's internal milieu. Although the importance of the body-to-brain communication that underlies interoception is implicit, the vagal afferent signalling and corresponding brain circuits that shape perception of the viscera are not entirely clear. Here, we use mice to parse neural circuits subserving interoception of the heart and gut.
View Article and Find Full Text PDFThe interplay between hypothalamic and brainstem nuclei in homeostatic control of energy balance.
Behav Brain Res
March 2025
Faculty of Health Sciences, University of Primorska, Izola, Slovenia. Electronic address:
Energy balance and body weight are tightly regulated by homeostatic and hedonic systems of the brain. These systems are ultimately finely tuned by hypothalamic and extrahypothalamic neurocircuitry that modulate feeding and the appetite signalling cascade. The hypothalamus has been extensively researched and its role in homeostatic regulation of energy balance is well established.
View Article and Find Full Text PDFSpinal Afferent Innervation From Left Dorsal Root Ganglia in the Flat-Mounts of Whole Atria of Rats: Anterograde Tracing.
J Comp Neurol
December 2024
Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA.
Article Synopsis
- The study investigates the spinal afferent innervation of the heart, focusing on how sensory information from the dorsal root ganglia (DRG) regulates cardiac functions.
- Researchers injected a tracer into the DRGs of male rats to map the distribution and morphology of spinal afferent axons in the heart, finding significant projections into the left and right atria.
- The findings highlight the presence and branching patterns of axons in different heart tissue layers, providing a foundational understanding for future research on cardiac spinal innervation and its implications in heart disease.
Transcutaneous vagus nerve stimulation improves emotional processing.
J Affect Disord
March 2025
Goethe University, University Hospital, Department of Psychiatry, Psychotherapy and Psychosomatics, Germany; Max-Planck Institute for Metabolism Research, Cologne, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. Electronic address:
Background: Invasive vagus nerve stimulation (iVNS) is approved for the treatment of major depressive disorder (MDD). The limited understanding of its underlying mechanisms, however, hinders stratification and the prediction of treatment response. Given the strong projections of the afferent vagal nucleus to brain regions involved in emotional processing, we tested whether acute transauricular VNS (taVNS) can improve emotional processing that is a core deficit in MDD.
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