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Basic Principles of Rotational Thromboelastometry (ROTEM) and the Role of ROTEM-Guided Fibrinogen Replacement Therapy in the Management of Coagulopathies.
Diagnostics (Basel)
October 2023
National Centre of Hemostasis and Thrombosis, Department of Hematology and Transfusiology, Jessenius Faculty of Medicine in Martin, University Hospital in Martin, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Rotational thromboelastometry (ROTEM) is a viscoelastic method, which provides a graphical and numerical representation of induced hemostasis in whole blood samples. Its ability to quickly assess the state of hemostasis is used in the management of bleeding from a variety of causes. The separate activation of particular parts of hemocoagulation in INTEM, EXTEM, and FIBTEM tests allows for a more comprehensive and faster evaluation of the missing component of hemostasis followed by targeted therapy.
View Article and Find Full Text PDFFibrinogenolysis in Venom-Induced Consumption Coagulopathy after Snakebites: A Pilot Study.
Toxins (Basel)
August 2022
Department of Anaesthesiology and Intensive Medicine, Toxinology Center, First Medical Faculty, Charles University, General University Hospital, U Nemocnice 499/2, 128 08 Prague, Czech Republic.
Envenomations that are caused by snakebites are mostly accompanied by venom-induced consumption coagulopathy (VICC) with defibrination. The clinical course of VICC is well described; however, reports about its detailed effects in the hemocoagulation systems of patients are sparse. In this pilot study, we prospectively analyzed the changes in plasma fibrinogen that were caused by the envenomation of six patients by five non-European snakes.
View Article and Find Full Text PDFObjective: It remains unclear whether atrial fibrillation (AF) alone determines systemic changes in hemocoagulation. Our aim was to examine the prothrombin fragment F1+2 and fibrinopeptide A (FPA) as early markers of coagulation activity still in the first twenty-four hours of paroxysmal AF (PAF) and to correlate them with the arrhythmia onset.
Methods: 51 non-anticoagulated patients (26 men, 25 women, aged 59.
The aim of this work was to study the reaction of coagulation hemostasis in response to hypoxia in rats young and mature, exposed to hypoxia in the embryonic, prefetal and fetal stages of prenatal ontogenesis. With the help of some hematological tests, a comparative analysis of blood coagulation indices was performed, both of males and females of experimental and control rats. To assess the general condition of the blood coagulation system, the time of clot formation, the time of plasma recalcification, and the concentration of fibrinogen were determined to assess the final stage.
View Article and Find Full Text PDFHemocoagulative post-operative changes after laparoscopic surgery compared to open surgery: the role of lupus anticoagulant.
Updates Surg
December 2020
Department of Surgery, University of Catania, Catania, Italy.
Although still debated, post-operative modification of hemostasis seems to be less pronounced after laparoscopy compared to open surgery. Antiphospholipid antibodies might play a role in the post-operative thromboembolic risk, although their evaluation in surgical patients has never been performed. Post-operative modification of antiphospholipid antibodies could be related to the surgical approach (laparoscopic or open).
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