Over the 3 years from 1982 to 1984, a total of 34 patients were seen in the Accident and Emergency Department of St Thomas' Hospital, London, as a result of the London Marathon. Clinical details are discussed. Considering the number of annual runners who take part, the casualties from the finish of this event are low. This short report suggests that the 3 years' preparation and organization for the finish of the London Marathon were consistently effective.
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http://dx.doi.org/10.1136/emj.2.2.89 | DOI Listing |
J Prev Alzheimers Dis
January 2025
Alzheimer's Drug Discovery Foundation, New York, NY, USA. Electronic address:
There is growing consensus in the Alzheimer's community that combination therapy will be needed to maximize therapeutic benefits through the course of the disease. However, combination therapy raises complex questions and decisions for study sponsors, from preclinical research through clinical trial design to regulatory, statistical, and operational considerations. In January 2024, the Alzheimer's Drug Discovery Foundation convened an expert advisory board to discuss the key considerations in each of these areas.
View Article and Find Full Text PDFJ Sci Med Sport
November 2024
Brighton Marathon Research Group, United Kingdom of Great Britain and Northern Ireland; Department of Intensive Care, University Hospitals Sussex, United Kingdom of Great Britain and Northern Ireland; Brighton and Sussex Medical School, United Kingdom of Great Britain and Northern Ireland. Electronic address: https://twitter.com/drlhodgson.
Nonsteroidal anti-inflammatory drug use is prevalent in sport however the risk associated with their use in athletes is not well-understood. This review discusses the pharmacology of nonsteroidal anti-inflammatory drugs and the prevalence of their use in different sports and factors driving this. Use is very high in sports such as professional football and is sometimes by routine without indication and without medical supervision.
View Article and Find Full Text PDFSports Med
December 2024
Insight Centre for Data Analytics, School of Computer Science, University College Dublin, Dublin, Ireland.
Background: The training characteristics and training intensity distribution (TID) of elite athletes have been extensively studied, but a comprehensive analysis of the TID across runners from different performance levels is lacking.
Methods: Training sessions from the 16 weeks preceding 151,813 marathons completed by 119,452 runners were analysed. The TID was quantified using a three-zone approach (Z1, Z2 and Z3), where critical speed defined the boundary between Z2 and Z3, and the transition between Z1 and Z2 was assumed to occur at 82.
J Sleep Res
October 2024
Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alzheimers Dement
November 2024
Rainwater Charitable Foundation, Fort Worth, Texas, USA.
The tauopathies are defined by pathological tau protein aggregates within a spectrum of clinically heterogeneous neurodegenerative diseases. The primary tauopathies meet the definition of rare diseases in the United States. There is no approved treatment for primary tauopathies.
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