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Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells.
Bioact Mater
March 2025
Institute for Mechanobiology, Department of Bioengineering, College of Engineering, Northeastern University, Boston, MA, 02115, USA.
The technology of induced pluripotent stem cells (iPSCs) has enabled the conversion of somatic cells into primitive undifferentiated cells via reprogramming. This approach provides possibilities for cell replacement therapies and drug screening, but the potential risk of tumorigenesis hampers its further development and application. How to generate differentiated cells such as valvular endothelial cells (VECs) has remained a major challenge.
View Article and Find Full Text PDFNiclosamide attenuates calcification in human heart valvular interstitial cells through inhibition of the AMPK/mTOR signaling pathway.
Biochem Pharmacol
December 2024
College of Pharmacy, Mokpo National University, 1666 Yeongsan-Ro, Cheonggye-Myeon, Muan-Gun, Jeonnam 58554, Republic of Korea. Electronic address:
Calcific aortic valve disease (CAVD) is a considerable health burden with a lack of effective therapeutic options. There is an urgent need to develop interventions that inhibit the osteogenic transformation of valvular interstitial cells (VICs) and delay the calcification process. Niclosamide, an FDA-approved anti-helminthic drug, has emerged as a promising candidate that demonstrates a negative regulatory effect on porcine VICs calcification.
View Article and Find Full Text PDFFeasibility and safety of pulsed field ablation at the ventricular outflow tract using focal point catheter.
Heart Rhythm
November 2024
Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Background: Ventricular arrhythmias commonly originate from the ventricular outflow tract. It remains unexplored whether pulsed field ablation (PFA) can create durable lesions safely at the ventricular outflow tract.
Objective: This study aimed to evaluate the feasibility and safety of a novel PFA catheter to deliver focal ablation to the ventricular outflow tract, especially pulmonary and aortic sinus cusps (PSCs and ASCs).
Computational Model for Early-Stage Aortic Valve Calcification Shows Hemodynamic Biomarkers.
Bioengineering (Basel)
September 2024
Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.
Heart disease is a leading cause of mortality, with calcific aortic valve disease (CAVD) being the most prevalent subset. Being able to predict this disease in its early stages is important for monitoring patients before they need aortic valve replacement surgery. Thus, this study explored hydrodynamic, mechanical, and hemodynamic differences in healthy and very mildly calcified porcine small intestinal submucosa (PSIS) bioscaffold valves to determine any notable parameters between groups that could, possibly, be used for disease tracking purposes.
View Article and Find Full Text PDFCharacterization of pediatric porcine pulmonary valves as a model for tissue engineered heart valves.
Acta Biomater
October 2024
Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, Toronto, Canada; Institute of Biomedical Engineering, University of Toronto, Toronto, Canada; Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Canada. Electronic address:
Heart valve tissue engineering holds the potential to transform the surgical management of congenital heart defects affecting the pediatric pulmonary valve (PV) by offering a viable valve replacement. While aiming to recapitulate the native valve, the minimum requirement for tissue engineered heart valves (TEHVs) has historically been adequate mechanical function at implantation. However, long-term in situ functionality of TEHVs remains elusive, suggesting that a closer approximation of the native valve is required.
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