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T Cell Dysregulation in Rheumatoid Arthritis: from Genetic Susceptibility to Established Disease.
Curr Rheumatol Rep
January 2025
Department of Rheumatology, Flinders Medical Centre, Adelaide, SA, Australia.
Purpose Of Review: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation of the synovial tissue, where T cells play a central role in pathogenesis. Recent research has identified T peripheral helper (Tph) cells as critical mediators of local B cell activation in inflamed tissues. This review synthesizes the latest advancements in our understanding the of the role of T cells in RA, from initiation to established disease.
View Article and Find Full Text PDFThe Role of Long Non-Coding RNA in Rheumatoid Arthritis.
Int J Mol Sci
January 2025
Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint damage and physical dysfunction. The pathogenesis of RA is highly complex, involving genetic, epigenetic, immune, and metabolic factors, among others. Over the years, research has highlighted the importance of non-coding RNAs (ncRNAs) in regulating gene expression.
View Article and Find Full Text PDFA comparative study of the effect of capsular repair in the Latarjet procedure.
BMC Musculoskelet Disord
January 2025
Gold Coast University Hospital, 1 Hospital Boulevard, Gold Coast, Southport, QLD, 4215, Australia.
Background: Long term studies have shown the Latarjet procedure to be successful in preventing re-dislocation in primary and recurrent anterior inferior shoulder instability. It provides stability through the sling effect of the conjoint tendon and the bone block. It is unclear whether augmentation with capsular repair provides an added benefit or leads to restricted range of external rotation.
View Article and Find Full Text PDF[Proximal iliotibial band tear: a case report in an amateur football player].
Acta Ortop Mex
January 2025
Universidade de Ribeirao Preto Campus Guarujá. Guarujá (SP), Brazil.
The iliotibial band originates from the iliac crest and the hip joint capsule, extending along the entire lateral surface until it inserts onto tuberculum anterolateralis tibiae on the anterolateral tibia. It acts as an agonist of the anterior cruciate ligament. In short, the iliotibial band primarily contributes to the lateral stabilization of the knee joint.
View Article and Find Full Text PDFJoint fluid multi-omics improves diagnostic confidence during evaluation of children with presumed septic arthritis.
Pediatr Rheumatol Online J
January 2025
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Background: An accurate diagnosis of septic versus reactive or autoimmune arthritis remains clinically challenging. A multi-omics strategy comprising metagenomic and proteomic technologies were undertaken for children diagnosed with presumed septic arthritis to advance clinical diagnoses and care for affected individuals.
Methods: Twelve children with suspected septic arthritis were prospectively enrolled to compare standard of care tests with a rapid multi-omics approach.
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