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Impact of race-based calculations of eGFR on the management of muscle invasive bladder cancer.
Am J Clin Exp Urol
December 2024
Division of Urology, Department of Surgery, School of Medicine, University of Maryland Baltimore, MD, USA.
Purpose: The estimated glomerular filtration rate (eGFR) has historically been calculated with a race-coefficient multiplier (RCM); however, the RCM has been broadly criticized as inaccurate and a potential contributor to exacerbating disparities. We evaluated the impact of the RCM on eGFR and examined the 30-day post-cystectomy complications in a muscle-invasive bladder cancer cohort.
Materials And Methods: We retrospectively analyzed patients diagnosed with MIBC who underwent cystectomy in the ACS NSQIP database from 2006 to 2020 using CPT and ICD codes.
Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease.
Front Med (Lausanne)
January 2025
Department of Internal Medicine, Texas Tech University Health Sciences Centre, Lubbock, TX, United States.
While changes in glomerular function and structure may herald diabetic kidney disease (DKD), many studies have underscored the significance of tubule-interstitial changes in the progression of DKD. Indeed, tubule-interstitial fibrosis may be the most important determinant of progression of DKD as in many forms of chronic glomerulopathies. The mechanisms underlying the effects of tubular changes on glomerular function in DKD have intrigued many investigators, and therefore, the signaling mechanisms underlying the cross-talk between tubular cells and glomerular cells have been the focus of investigation in many recent studies.
View Article and Find Full Text PDFEvaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants.
Front Nephrol
January 2025
Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Background: This study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of multiple donors and paired kidney exchanges.
Methods: Using data from the Scientific Registry of Transplant Recipients (SRTR), we retrospectively analyzed graft survival in adult LDKT recipients transplanted between January 2013 and September 2022. Recipients with 0 HLA-DR mismatches were compared to those with 1-2 HLA-DR mismatches.
The rotation method for correcting renal depth in the determination of glomerular filtration rate using Tc-99m diethylenetriamine pentaacetic acid (DTPA)-based renal dynamic imaging in patients with hydronephrosis.
Quant Imaging Med Surg
January 2025
Department of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, China.
Background: Kidney depth significantly affects the accuracy of glomerular filtration rate (GFR) measurement, and hydronephrosis-induced morphological changes further challenge its estimation through traditional formulas. This study evaluated the rotation method's efficacy in correcting kidney depth and depth difference during Tc-99m diethylenetriamine pentaacetic acid (DTPA) renal dynamic imaging for GFR assessment.
Methods: This study analyzed 66 individuals treated at First Hospital of Shanxi Medical University with unilateral hydronephrosis between January 2022 and June 2023.
Evaluation of efficacy and safety of generic tacrolimus (Suprotac®) compared to reference tacrolimus (Prograf) in kidney transplantation: a phase IV study.
Eur J Transl Myol
January 2025
CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj.
Background: Transplant recipients are given an immunosuppressive regimen such as tacrolimus to prevent organ rejection. Suprotac® is a generic tacrolimus that is utilized in kidney transplantation regimen in Iran. This post-market study was conducted to evaluate the safety and efficacy of Suprotac® in comparison with Prograf®.
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