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Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy.
Sci Rep
January 2025
Division of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Myocyte disarray and fibrosis are underlying pathologies of hypertrophic cardiomyopathy (HCM) caused by genetic mutations. However, the extent of their contributions has not been extensively evaluated. In this study, we investigated the effects of genetic mutations on myofiber function and fibrosis patterns in HCM.
View Article and Find Full Text PDFUnmasking the Hidden Threat: The Role of Left Ventricular Subendocardial Involvement in Autoimmune Rheumatic Disease.
Clin Cardiol
January 2025
Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: Late gadolinium enhancement (LGE) has been found in patients with autoimmune rheumatic disease (ARD). However, the prognostic implications of some specific LGE patterns in ARD patients remain unclear.
Purpose: To investigate the prevalence and prognostic significance of left ventricular (LV) subendocardium-involved LGE (LGEse) in a cohort of ARD patients.
Much More Than a Stroke: Emery-Dreifuss Muscular Dystrophy Type 2 Revealed by Ischemic Stroke.
Cureus
November 2024
Stroke Unit, Centro Hospitalar Tondela-Viseu, Viseu, PRT.
Emery-Dreifuss muscular dystrophy type 2 (EDMD2) is a rare autosomal dominant neuromuscular disorder caused by LMNA gene mutations and characterized by progressive skeletal muscle weakness and significant cardiac involvement. We report the case of a 45-year-old woman who presented with sudden-onset, left-sided hemiparesis and dysarthria. Initial imaging was unremarkable, and symptoms transiently improved, suggesting a transient ischemic attack.
View Article and Find Full Text PDFMagnetization-transfer flow-independent dark-blood delayed enhancement cardiac MRI optimizes discrimination of ST-elevation myocardial infarct borders.
Eur Radiol
December 2024
University Clinic of Radiology, Medical University of Innsbruck, A-6020, Innsbruck, Austria.
Article Synopsis
- This study compares the image quality and methods for measuring infarct size between a new technique called MT-FIDDLE and the standard bright-blood LGE cardiac MRI in patients who had a heart attack (STEMI).
- The results indicate that MT-FIDDLE provides significantly better subjective image quality, particularly in terms of confidence for infarct segmentation and blood-pool contrast, with a high concordance in infarct volume measurements compared to bright-blood LGE.
- Ultimately, MT-FIDDLE proved to enhance the ability to differentiate between heart injury (myocardial infarction) and surrounding blood, suggesting it could be a superior imaging method for assessing heart damage after a STEMI.
Eosinophilic granulomatosis with polyangiitis associated with malignant arrhythmias: a case report.
Eur Heart J Case Rep
November 2024
Department of Cardiology, Jersey General Hospital, Gloucester Street, St. Helier, JE1 3QS, Jersey.
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare vasculitis associated with significant cardiac morbidity and mortality. This case report presents the diagnostic and management challenges of EGPA-related arrhythmias in a remote general hospital setting.
Case Summary: A 64-year-old Caucasian male presented with an indolent prodrome of fatigue, shortness of breath and anorexia, that culminated in an acute presentation with pulmonary embolism.
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