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Aptazyme-directed A-to-I RNA editing.

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January 2025

Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Science, Chengdu, P.R. China. Electronic address:

As a promising therapeutic approach, the RNA editing process can correct pathogenic mutations and is reversible and tunable, without permanently altering the genome. RNA editing mediated by human ADAR proteins offers unique advantages, including high specificity and low immunogenicity. Compared to CRISPR-based gene editing techniques, RNA editing events are temporary, which can reduce the risk of long-term unintended side effects, making off-target edits less concerning than DNA-targeting methods.

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Fatigue-Limit Assessment via Infrared Thermography for a High-Strength Steel.

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Standards & Metrology Research Institute, China Academy of Railway Sciences Corporation Limited, Beijing 100010, China.

Infrared thermography techniques have proven to be very effective for assessing the fatigue limits of metallic materials with obvious temperature variations. But for some materials, it has been shown that the temperature variation is very limited, and the accuracy of infrared thermographic techniques is not verified. In this study, the fatigue properties of a high-strength steel (SAE52100) were evaluated with traditional fatigue-loading techniques and infrared thermographic methods.

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Background: The pairing assistance policy represents a distinctive instrument utilized by the Chinese government to address major public crises. This study examines the development of a pairing assistance policy by the Chinese Government through its central authority to foster collaborative governance among local governments in areas affected by COVID-19.

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