AI Article Synopsis
- Between 1975 and 1982, 38 patients with large, locally advanced head and neck cancer tumors attached to the carotid artery underwent surgery followed by iodine 125 suture implants, aiming to treat residual disease.
- The local control rate for the treated area was 79%, with an overall local and regional control rate of 53% and a mean survival time of 11 months.
- The procedure had a complication rate of 26%, but results showed no significant impact of various treatment factors on local control or complications, suggesting that this method is a viable alternative to more invasive options.
Article Abstract
Between 1975 and 1982, 38 patients with locally advanced head and neck cancer attached to the carotid artery underwent surgical excision followed by iodine 125 vicryl suture implant in the neck. Most patients had neck masses that were greater than 6 cm and stage IV disease without clinically evident distant metastases. Twelve patients had received no previous therapy while 26 underwent an implant for recurrent disease. The local control rate in the implant volume was 79%. The local and regional control rate in all head and neck sites was 53%. The mean survival was 11 months. The overall complication rate was 26%. There was no significant correlation of local control or complications with the minimum total dose, volume implanted, individual 125I seed strength, or total seed strength. In patients with large masses attached to the carotid artery, surgical resection followed by a 125I implant for residual disease is a viable alternative to resection of the carotid artery.
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| http://dx.doi.org/10.1200/JCO.1985.3.6.809 | DOI Listing |
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