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Early-Life Risks of Central Precocious Puberty. | LitMetric

Early-Life Risks of Central Precocious Puberty.

Endocr Pract

Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:

Published: March 2025

Objectives: To investigate the factors in early life that may contribute to central precocious puberty (CPP) METHODS: The study utilized data from the Taiwan Puberty Longitudinal Study (TPLS), including 2,241 children under pubertal assessment and a questionnaire of risk factors. We analyzed associations using Fitting Generalized Linear Models in R.

Results: Among the 2,241 children examined, 745 had CPP. Overall, higher gestational weight gain (GWG) increased the risk of CPP (OR: 1.03, 95% CI: 1.01-1.05); while higher GWG served as a protective factor in females (OR: 0.97, 95% CI: 0.95-0.99). Maternal gestational diabetes mellitus (GDM) also increased the CPP risk, particularly in males (OR: 2.66, 95% CI: 1.00-7.25). Longer exclusive breastfeeding (EBF) was linked to lower CPP risk overall (OR: 0.96, 95% CI: 0.93-1.00) but was not significant when analyzed by gender.

Conclusions: Higher maternal GWG was associated with an increased risk of CPP overall, while GWG became negatively associated with CPP, only in females. Maternal GDM was linked to a higher risk of CPP, particularly in males. The duration of EBF was inversely correlated with CPP risk, but this effect was not significant when analyzed by gender.

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Source
http://dx.doi.org/10.1016/j.eprac.2025.03.004DOI Listing

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