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Musculoskeletal Tuberculosis (TB) affects the bones, joints and soft tissues and accounts for 1-3 % of TB cases worldwide. The onset of symptoms is usually insidious and nonspecific. It may lead to irreversible joint damage, deformities or neurological manifestations necessitating surgical and rehabilitative corrections due to delayed diagnosis and prolonged latency in the initiation of definitive medical treatment. The axial skeleton, particularly the thoracic and lumbar regions, is the most commonly involved site, followed by the hips and knees in peripheral joints. Given the rising prevalence of TB in developing countries and the emergence of drug-resistant strains, understanding musculoskeletal TB's pathophysiology, clinical manifestations, and management strategies remains critical for improving patient outcomes. In addition, non-tuberculous mycobacterial infections, para-infectious manifestation, and achieving adequate disease control in a setting of immune-mediated inflammatory disorders pose significant diagnostic and therapeutic challenges.
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http://dx.doi.org/10.1016/j.berh.2025.102057 | DOI Listing |
Best Pract Res Clin Rheumatol
March 2025
JSS Academy of Higher Education and Research, Mysuru, Karanataka, India. Electronic address:
Musculoskeletal Tuberculosis (TB) affects the bones, joints and soft tissues and accounts for 1-3 % of TB cases worldwide. The onset of symptoms is usually insidious and nonspecific. It may lead to irreversible joint damage, deformities or neurological manifestations necessitating surgical and rehabilitative corrections due to delayed diagnosis and prolonged latency in the initiation of definitive medical treatment.
View Article and Find Full Text PDFBMC Rheumatol
March 2025
Musculoskeletal Innovative Research Lab (mskil), University of Liège, Liège, Belgium.
Objectives: Osteoarthritis (OA), a prevalent and disabling condition, significantly burdens individuals and healthcare systems worldwide. It is characterized by joint pain, stiffness, and structural changes in cartilage, bone, and synovium. The clinical manifestations of OA vary widely, reflecting complex interactions among genetic, metabolic, biomechanical, and environmental factors.
View Article and Find Full Text PDFBest Pract Res Clin Rheumatol
March 2025
Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA. Electronic address:
Sarcoidosis is a complex multisystem inflammatory disease characterized by noncaseating granulomas and variable clinical manifestations, most commonly affecting the lungs, skin, heart, and nervous system. Imaging is central in its diagnosis, staging, and management, providing essential insights into organ involvement and disease activity. Pulmonary manifestations remain the hallmark, with modalities such as high-resolution chest computed tomography (CT) and chest radiography offering critical diagnostic clues.
View Article and Find Full Text PDFSemin Immunol
March 2025
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
In celiac disease (CeD), dietary gluten serves as the driver for a comparatively well characterized small bowel mucosal immune response that generally results in small bowel mucosal villous atrophy and crypt hyperplasia along with a disease-specific transglutaminase 2 (TG2) targeting autoantibody response. Individuals with positive TG2 autoantibodies but normal small intestinal mucosal morphology are regarded at increased risk of developing CeD and represent patients with potential CeD. The removal of gluten from the diet leads to disappearance of the autoantibodies and normalization of the mucosal architecture in most cases.
View Article and Find Full Text PDFJBJS Case Connect
January 2025
Boston Children's Hospital, Boston, Massachusetts.
Case: We present a unique case of bilateral ulnar longitudinal deficiency (ULD) with concurrent postaxial polydactyly (PAPD) in a 2-month-old boy, an association that has not previously been described.
Conclusion: ULD, a rare musculoskeletal anomaly, often manifests with complex digital abnormalities. ULD may be associated with other musculoskeletal differences and congenital heart anomalies, necessitating comprehensive evaluation.
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