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Case Presentation: A 30-year-old man presented with a multilobulated left parotid mass measuring 5.2 × 4.1 × 2.4 cm by imaging, and numerous enlarged left cervical lymph nodes, suspicious for metastasis. FNA cytopathology of the mass showed loose clusters of large cells displaying increased N/C ratios and ample granular oncocytic cytoplasm. A superficial left parotidectomy with radical resection of the cheek and cervical lymphadenectomy was performed. Histopathologic examination disclosed a circumscribed, unencapsulated neoplasm exhibiting a solid growth pattern composed of infiltrative islands and nests of cohesive, polygonal, oncocytoid cells in a densely fibrous stroma. Lesional cells exhibited enlarged, oval, open-face nuclei with coarse chromatin and a single acidophilic macronucleolus, voluminous eosinophilic granular cytoplasm and distinct cell membrane borders. Mitotic activity and necrosis were absent. Microcystic architecture was noted solely in a single tumor nest at the periphery. These spaces contained mucinous secretions and were lined by cuboidal oncocytic and intermediate cells with interspersed mucocytes, highlighted by mucicarmine stain. Immunohistochemically, oncocytic cells were strongly and diffusely positive for cytokeratin AE1/AE3, p63 and p40, and uniformly negative for androgen receptor, GATA3, S100, SOX10 and Her-2. A MAML2 rearrangement was identified by FISH, thus confirming the diagnosis of oncocytic variant of mucoepidermoid carcinoma.
Conclusion: In this illustrative example, we present the clinicoradiologic, cytologic, histopathologic, and immunophenotypic characteristics of this rare variant of mucoepidermoid carcinoma, together with molecular documentation.
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http://dx.doi.org/10.1007/s12105-025-01768-0 | DOI Listing |
Ann Clin Lab Sci
January 2025
Department of Pathology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Objective: Salivary gland neoplasms are rare in pediatric and adolescent populations. Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary glands that most frequently arises in the parotid gland as a painless swelling. Herein we present a rare case of MEC in a child with metastasis to the cervical lymph node as primary presentation.
View Article and Find Full Text PDFHead Neck Pathol
March 2025
Department of Pathology, The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.
Case Presentation: A 30-year-old man presented with a multilobulated left parotid mass measuring 5.2 × 4.1 × 2.
View Article and Find Full Text PDFOral Dis
March 2025
Department of Oral Pathology, School of Dentistry, Federal University of Pará, Belém, Brazil.
Objective: This study aimed to assess the expression of invadopodia-related proteins in mucoepidermoid carcinoma and their influence on this tumor's invasiveness.
Material And Methods: Twenty-seven mucoepidermoid carcinoma grading samples were evaluated for the expression of Tks4, Tks5, cortactin, and MT1-MMP and compared to 10 control samples of normal-looking salivary glands by immunohistochemistry. For in vitro analysis, immunofluorescence identified the expression of invadopodia-related proteins in the mucoepidermoid carcinoma cell line.
Indian J Otolaryngol Head Neck Surg
February 2025
Department of ENT, Command Hospital- Eastern Command, Kolkata, India.
Unlabelled: Sino-nasal malignancies are extremely rare accounting < 1% of all malignancies and < 3% of aero-digestive tract tumors. Their surgical pathology is extremely challenging due to the enormous heterogeneity. Few of these sino-nasal tumors may possibly present histologically as clear cell neoplasm.
View Article and Find Full Text PDFDiagn Cytopathol
April 2025
Department of Pediatric Oncology, Institut Curie, Paris cedex, France.
Keratocystoma is a rare benign salivary gland tumor described in 1999. Only 14 cases have been reported in the histopathological literature, with three of them having had a preoperative fine needle aspiration (FNA) performed. All cytological diagnoses were not specific.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!