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P2X receptors (P2XRs), membrane ion channels activated by extracellular adenosine 5' -triphosphate (ATP), play a pivotal role in nociception by directly promoting pain signaling. Currently, antagonists targeting P2XRs have taken effect in alleviating various pain. The therapeutic potential of the P2X receptor family has become a central focus. Consequently, numerous research groups and pharmaceutical companies are actively engaged in developing novel P2XR antagonists. Furthermore, an increasing number of clinical trials on P2XR antagonists have obtained encouraging results. This review provides an overview of the structural characteristics and cellular localization of P2XRs, their molecular mechanisms and signaling pathways implicated in orofacial pain. Additionally, it explores the development of P2XR antagonists and their therapeutic application for managing orofacial pain. In conclusion, this review highlights the promising role of P2XRs as therapeutic targets for orofacial pain treatment.
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http://dx.doi.org/10.1016/j.brainresbull.2025.111301 | DOI Listing |
J Stomatol Oral Maxillofac Surg
March 2025
Maxillofacial Surgery Department, Hôpital de la Croix Rousse, 103 grande rue de la Croix Rousse, 69004 Lyon, France; Maxillofacial Surgery Department, Hôpital Nord, Avenue Albert Raimond, 42000 Saint-Priest-en-Jarez, France.
Purpose: New-generation total temporomandibular joint prostheses have demonstrated their efficacy and low morbidity. However, their implantation requires a dual external approach, which can result in significant aesthetic and functional sequelae. The authors have therefore developed an alternative technique that avoids the cervical route.
View Article and Find Full Text PDFLasers Med Sci
March 2025
Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.
Reports on the use of plasma skin regeneration for the treatment of acne vulgaris are limited. We aimed to report on the effectiveness of nitrogen PSR in the treatment of acne vulgaris. Participants with acne vulgaris were enrolled and underwent three consecutive PSR sessions at 4-week intervals.
View Article and Find Full Text PDFLaryngoscope
March 2025
Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville, Virginia, USA.
Objective: Occult lesions involving the facial nerve can be misdiagnosed as idiopathic facial paralysis, also known as Bell's palsy. Our goal was to compare the clinical features of patients with idiopathic/viral versus non-idiopathic facial paralysis and identify predictors of malignant etiologies.
Methods: Retrospective chart review of 276 patients referred for surgical management of facial paralysis at two large facial nerve tertiary care centers.
Ann Indian Acad Neurol
March 2025
Department of Algology, Etlik City Hospital, Ankara, Turkey.
Background And Objectives: The majority of patients with persistent idiopathic facial pain (PIFP) do not respond to conservative treatment and thus require alternative therapeutic modalities. This study compared the effects of transnasal and ultrasound (US)-guided suprazygomatic approaches for sphenopalatine ganglion (SPG) block on pain management in refractory PIFP.
Methods: This study included 38 patients with PIFP who underwent transnasal (Group T, n = 18) and US-guided suprazygomatic (Group U, n = 20) SPG block.
Br Dent J
March 2025
Department of Orthodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.
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