TRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development. This review focuses on the role of TRP channels in the development of breast cancer, including their involvement in proliferation, apoptosis, autophagy, metastasis, and angiogenesis. TRP channels are associated with breast carcinogenesis and their role as potential therapeutic targets and prognostic biomarkers is under investigation. This review summarizes the reported effects of inhibiting or agonizing various TRP channel in breast cancer cells. Although there are relatively mature protocols for the treatment of breast cancer, its treatment is not currently a breakthrough, and therapies targeting TRP channels may be a developable strategy for it.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11896876 | PMC |
| http://dx.doi.org/10.3389/fmolb.2025.1528663 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
TRP channels and breast cancer: the role of TRPs in the pathophysiological development.
Front Mol Biosci
February 2025
Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, School of Medicine, Huzhou University, Huzhou, China.
TRP channels play important roles in regulating various physiological and pathological processes, including the progression of cancer. Several TRP channels mediate tumour development. This review focuses on the role of TRP channels in the development of breast cancer, including their involvement in proliferation, apoptosis, autophagy, metastasis, and angiogenesis.
View Article and Find Full Text PDFManaging a Burning Face: Clinical Manifestations and Therapeutic Approaches for Neurogenic Rosacea.
Int J Mol Sci
March 2025
Escuela de Medicina, Universidad de Tarapacá, Arica 1000000, Chile.
Rosacea is a common chronic inflammatory condition primarily affecting middle-aged women. It presents with flushing, erythema, telangiectasia, papules, pustules, phymatous changes, and ocular involvement. Although typically grouped into four subtypes-erythematotelangiectatic, papulopustular, ocular, and phymatous-overlapping features often favor a phenotypic diagnostic approach.
View Article and Find Full Text PDFComparative Hypothalamic Proteomic Analysis Between Diet-Induced Obesity and Diet-Resistant Rats.
Int J Mol Sci
March 2025
College of Medical Technology, Tianjin Medical University, Tianjin 300203, China.
Obesity arises from a complex interplay of genetic and environmental factors. Even among individuals with the same genetic predisposition, diet-induced obesity (DIO) exhibits varying degrees of susceptibility, which are categorized as DIO and diet-induced obesity resistance (DR). The hypothalamus plays a pivotal role in regulating energy homeostasis.
View Article and Find Full Text PDF[Acupuncture regulates dynamic flux of Ca, Na, and HO in skeletal muscle injury induced by eccentric exercise in rats].
Sheng Li Xue Bao
February 2025
College of Life Sciences, Huzhou Normal University, Huzhou 313000, China.
This study aimed to investigate the effects of acupuncture on dynamic changes in Ca, Na, and HO flux following eccentric exercise-induced muscle injury. The total of 324 healthy male Wistar rats were randomly divided into 6 groups: control group (C), eccentric exercise group (E), eccentric exercise with acupuncture group (EA), EA with TRP channel blocker group (EAT), EA with NOX2 blocker group (EAN) and EA with placebo group (EAP). Gastrocnemius muscles were subject to lengthening contractions with percutaneous electrical stimulation, followed by immediate pretreatment with blocking agents.
View Article and Find Full Text PDFExploiting TRP channel diversity in insects: a pathway to next-generation pest management.
Arch Toxicol
March 2025
ICAR-Indian Agriculture Research Institute, New Delhi, 110012, India.
Transient Receptor Potential (TRP) channels, a diverse family of over 30 ion channel subtypes, are pivotal in regulating sensory perception, thermoregulation, and feeding in insects. In Drosophila melanogaster, 13 TRP channels have been identified, while Aedes aegypti and Anopheles gambiae possess 11 and 10, respectively, showcasing evolutionary adaptations to their ecological niches. This review explores recent advancements in understanding the structure, classification, and physiological functions of TRP channels, emphasizing their evolutionary divergence across Diptera, Lepidoptera, and Hymenoptera.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!