Surface-enhanced Raman spectroscopy is a powerful analytical technique for the determination of analytes with the advantages of sensitivity, portability, and simplicity, able to provide structural information for the identification of compounds. However, when it comes to the analysis of complex samples, matrix components may interfere with the analyte quantification. To overcome this shortcoming, a number of approaches have been proposed, such as extraction techniques. Among them, the coupling of chromatography with surface-enhanced Raman spectroscopy seems to be promising. It allows combining the advantages of both techniques, i.e., high efficiency of chromatographic separation and high sensitivity of surface enhanced Raman scattering detection, and makes possible simultaneous quantification of multiple analytes. The review summarizes the latest achievements in the combination of these techniques.
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| http://dx.doi.org/10.3389/fchem.2025.1548364 | DOI Listing |
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Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, P. R. China.
Since its discovery in 1997, the single molecule surface-enhanced Raman spectroscopy (SM-SERS) has attracted wide interest owing to its enormous potential in many fields. However, the commercialized applications of SM-SERS are still limited by the lack of a clear understanding of the relevant mechanism in the famous SM-SERS experiments. In this study, a salt-gradient model is proposed to deeply investigate the physical nature and update insights into the morphological, structural, and component evolution processes of Ag NPs from dispersed nanostructures to aggregation states in the salt-induced aggregation SERS strategy.
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Faculty of Material Sciences, Shenzhen MSU-BIT University, Shenzhen, China.
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Department of Nephrology, The First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, PR China. Electronic address:
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DSc, Professor, Department of Biophysics, Faculty of Biology; Lomonosov Moscow State University, 1 Leninskiye Gory, Moscow, 119991, Russia; Professor, Department of Physical Materials; National University of Science and Technology "MISIS", 4 Leninsky Prospect, Moscow, 119049, Russia.
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