Introduction: Tobacco use is as a major public health concern around the world, adversely impacting quality of life. Our study aims to analyze the trends in the burden of tobacco-related neurological disorders (ND) at global, regional, and national levels from 1990 to 2021, as well as potential future trends.
Methods: We performed a secondary dataset analysis for the assessment of mortality and disability-adjusted life years (DALYs) using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, to explore the burden of tobacco-related ND. We also analyzed the associations between the burden of ND and factors such as age, gender, and the Sociodemographic Index (SDI).
Results: In 2021, the age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) for neurological disorders were 0.50 per 100000 persons (95% UI: -0.15-1.98) and 11.25 per 100000 persons (95% UI: 1.36-34.36), respectively. Alzheimer's disease and other dementias (ADOD) had a particularly significant impact on the burden of ND. However, the ASDR for Parkinson's disease was -8.38 per 100000 persons (95% UI: -10.72 - -6.20). The burden of disease was greater in men and older people, with substantial regional variation. While aging and population growth might contribute to the increase in DALYs for tobacco-related ND, epidemiological changes have the potential to reduce the burden. From 2022 to 2050, the BAPC model predicted a decline in the age-standardized rate (ASR) of DALYs and mortality for tobacco-related ND, globally.
Conclusions: Tobacco use increased the burden of ND such as ADOD and multiple sclerosis (MS), while reducing the burden of Parkinson's disease (PD). The burden of disease was disproportionately higher among older individuals and males, with significant disparities across nations and regions. Over the past 32 years, the burden of these diseases has gradually decreased, and this trend is expected to continue from 2022 to 2050.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897908 | PMC |
| http://dx.doi.org/10.18332/tid/201966 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Assessing the safety of increased outpatient cephalosporin use following the modification of penicillin allergy cross-reactivity alerts.
Infect Control Hosp Epidemiol
March 2025
Department of Pharmaceutical Care, University of Iowa Health Care, Iowa City, IA, USA.
Background: Concerns about penicillin-cephalosporin cross-reactivity have historically led to conservative prescribing and avoidance of cephalosporins in patients with penicillin allergy labels, potentially causing suboptimal outcomes. Recent evidence suggests a lower risk of cross-reactivity, prompting a reassessment of alert systems.
Objective: To assess the impact of limited penicillin cross-reactivity alerts on outpatient cephalosporin use and the incidence of adverse reactions in a healthcare setting.
Developing and Implementing a Colorectal Cancer Screening Program in Uganda: Stakeholder Perceived Barriers and Opportunities.
Cancer Med
March 2025
Centre for Public Health, Queen's University Belfast, Belfast, UK.
Introduction: Colorectal cancer (CRC) incidence is increasing in Uganda. Despite this, and the disproportionately high burden of early onset and late-stage CRC cases, no CRC screening program exists in Uganda. To guide and inform future CRC prevention efforts, interviews with key stakeholders were undertaken to better understand the perceived barriers and opportunities relevant to the development and implementation of a CRC screening program in Uganda.
View Article and Find Full Text PDFFemtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles.
Nanomedicine (Lond)
March 2025
Department of Chemistry and The Institute for Laser, Photonics, and Biophotonics, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Background: Nanomedicine offers a number of innovative strategies to address major public health burdens, including complex respiratory illnesses. In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation for the treatment of influenza, SARS-CoV-2, and their co-infections.
Methods: The SARS-CoV-2 antiviral, remdesivir; the influenza antiviral, baloxavir marboxil; and the anti-inflammatory, dexamethasone, were co-crystalized and then ablated in aqueous media using a femtosecond pulsed laser and subsequently surface modified with the cationic polymer, chitosan, or poly-d-lysine.
Prevalence of co-morbid anxiety and depression in pregnancy and postpartum: a systematic review and meta-analysis.
Psychol Med
March 2025
Department of Clinical Nursing, Xiangya Nursing School of Central South University, Changsha, China.
The prevalence of co-morbid anxiety and depression varies greatly between research studies, making it difficult to understand and estimate the magnitude of this problem. This systematic review and meta-analysis aim to provide up-to-date information on the global prevalence of co-morbid anxiety and depression in pregnant and postpartum women and to further investigate the sources of heterogeneity. Systematic searches of eight electronic databases were conducted for original studies published from inception to December 10, 2024.
View Article and Find Full Text PDFThe Psychobiological Toll of Chronic Conflict: Posttraumatic Stress Symptoms, Emotion Dysregulation, and Physiology in a Conflict-Exposed Community in South Sudan.
Chronic Stress (Thousand Oaks)
March 2025
Department of Psychology, The New School for Social Research, New York, USA.
Background: Mass conflict and related displacement in South Sudan has created a significant mental health need, however extant research on the impact of conflict is limited among South Sudanese people and has predominantly relied on Western-developed self report measures.
Method: A total of 195 South Sudanese adults who work in both civil society and government leadership positions participated in a psychophysiological assessment of heart rate variability (HRV) and self-reported PTSD and emotion dysregulation symptoms to participation in the Trauma-Informed Community Empowerment (TICE) Framework, developed and implemented by the Global Trauma Project (GTP). We utilized measures of heart rate variability to determine parasympathetic activity, which may be associated with difficulties responding to stressors as well as long-term physical health morbidity and mortality.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!