In this review, we explore the transformative role of Ultrasound Biomicroscopy (UBM) in veterinary ophthalmology, focusing on its utility in evaluating the iridocorneal angle and ciliary body in dogs. We begin by outlining UBM's foundational principles, providing a holistic understanding of its operational mechanics. This is followed by an exploration of the techniques and considerations for optimal UBM imaging, including the use of topical anesthesia, probe positioning, and maintaining a controlled measurement environment. A major section is dedicated to the detailed anatomy of the anterior segment, emphasizing the iridocorneal angle and ciliary body in controlling aqueous humor dynamics within canine and feline eyes. By comparing anatomical structures in humans and animals, we highlight the need for distinct parameters in veterinary medicine. The review also analyzes the parameters obtainable via UBM, emphasizing its potential in monitoring drug-induced ocular changes, gaging post-cataract surgical outcomes, and observing inter-species variations. We conclude by encapsulating the current state of research, addressing existing challenges, and suggesting future research avenues. This synthesis underscores the pivotal role of UBM in advancing veterinary ophthalmic diagnostics and research.
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http://dx.doi.org/10.3389/fvets.2025.1501405 | DOI Listing |
Front Vet Sci
February 2025
Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
In this review, we explore the transformative role of Ultrasound Biomicroscopy (UBM) in veterinary ophthalmology, focusing on its utility in evaluating the iridocorneal angle and ciliary body in dogs. We begin by outlining UBM's foundational principles, providing a holistic understanding of its operational mechanics. This is followed by an exploration of the techniques and considerations for optimal UBM imaging, including the use of topical anesthesia, probe positioning, and maintaining a controlled measurement environment.
View Article and Find Full Text PDFSaudi J Ophthalmol
October 2024
Department of Ophthalmology, Hospital Santa Maria (ULSSM), Lisbon, Portugal.
Purpose: Phacoemulsification cataract surgery (PCS) is known to change anterior chamber morphology, widening the iridocorneal angle (ICA) of most patients. This study aims to determine whether automated gonioscopy imaging (AGI) with GS-1 (NIDEK CO., Japan) can detect changes in ICA morphology and pigmentation after PCS.
View Article and Find Full Text PDFJ Control Release
March 2025
Department of Pharmaceutical Sciences, College of Pharmacy, Robertson Life Sciences Building, Oregon State University, Portland, OR 97201, USA; Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA; Department of Biomedical Engineering, Robertson Life Sciences Building, Oregon Health & Science University, Portland, OR 97201, USA. Electronic address:
Lipid nanoparticles (LNPs) have shown great potential in the field of gene therapy for retinal diseases. To expand on this application, we investigated LNP-mediated mRNA delivery to the anterior chamber of the eye via the intracameral (IC) route of administration. Here, we show that IC injections of LNPs facilitated protein expression and gene editing in the trabecular meshwork (TM).
View Article and Find Full Text PDFExp Eye Res
March 2025
Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200031, China; NHC Key Laboratory of Myopia, Chinese Academy of Medical Sciences, And Shanghai Key Laboratory of Visual Impairment and Restoration (Fudan University), Shanghai, 200031, China. Electronic address:
The periocular mesenchyme (POM) gives rise to key structures in the ocular anterior segment, and its malformation leads to anterior segment dysgenesis (ASD) with iridocorneal angle (ICA) abnormalities. However, the transcriptional profile of the POM and the regulatory mechanisms governing cell-fate decision during anterior eye and ICA development remain poorly understood. In this study, we performed a comprehensive time-series analysis by sequencing rat anterior ocular samples collected at five consecutive perinatal stages: embryonic days 16.
View Article and Find Full Text PDFFront Vet Sci
December 2024
Laboratory of Veterinary Surgery and Ophthalmology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Introduction: This study aimed to examine the relationship between the relative opening of the ICA (RO-ICA) and the structure of the ciliary cleft (CC) using Ultrasound Biomicroscopy (UBM).
Materials And Methods: Clinical data from 31 eyes of 17 dogs at the Veterinary Teaching Hospital of Chungbuk National University, Korea, were analyzed. RO-ICA was categorized as "Slightly Narrow", "Narrow", "Open", and "Wide Open", with eyes further grouped into "Narrow" (including Slightly Narrow and Narrow) and "Open" (including Open and Wide Open) for analysis.
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