One of the core risk management tasks is to identify hidden high-risk states that may lead to system breakdown, which can provide valuable early warning knowledge. However, due to the high dimensionality and nonlinear interactions embedded in large-scale complex systems like urban traffic, it remains challenging to identify hidden high-risk states from huge system state space where over 99% of possible system states are not yet visited in empirical data. Based on the maximum entropy model, we infer the underlying interaction network from complicated dynamical processes of urban traffic and construct the system energy landscape. In this way, we can locate hidden high-risk states that may have never been observed from real data. These states can serve as risk signals with a high probability of entering hazardous minima in the energy landscape, which lead to huge recovery cost. Our findings might provide insights for complex system risk management.
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http://dx.doi.org/10.1093/pnasnexus/pgaf075 | DOI Listing |
PNAS Nexus
March 2025
School of Reliability and Systems Engineering, Beihang University, Beijing 100191, China.
One of the core risk management tasks is to identify hidden high-risk states that may lead to system breakdown, which can provide valuable early warning knowledge. However, due to the high dimensionality and nonlinear interactions embedded in large-scale complex systems like urban traffic, it remains challenging to identify hidden high-risk states from huge system state space where over 99% of possible system states are not yet visited in empirical data. Based on the maximum entropy model, we infer the underlying interaction network from complicated dynamical processes of urban traffic and construct the system energy landscape.
View Article and Find Full Text PDFPsychol Med
March 2025
Orygen, Parkville, VC, Australia.
Background: To improve early intervention and personalise treatment for individuals early on the psychosis continuum, a greater understanding of symptom dynamics is required. We address this by identifying and evaluating the movement between empirically derived attenuated psychotic symptomatic substates-clusters of symptoms that occur within individuals over time.
Methods: Data came from a 90-day daily diary study evaluating attenuated psychotic and affective symptoms.
Cardiol Res
April 2025
Cardiology Department, Hospital Universitario de La Princesa, Universidad Autonoma de Madrid, Madrid, Spain.
Background: The detection of underlying paroxysmal atrial fibrillation (AF) in patients with cryptogenic stroke (CS) can be challenging, and there is great interest in finding predictors of its hidden presence. The recent development of sophisticated software has enhanced the diagnostic and prognostic performance of the 12-lead electrocardiogram (ECG). Our aim was to assess the additional role of a computer-assisted ECG analysis in identifying predictors of AF in patients with CS.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
April 2025
Renal Medicine, Birmingham Heartlands Hospital, Birmingham, UK.
Background: Haemodialysis patients are at high risk of myopenic obesity, necessitating effective nutritional status monitoring and intervention strategies. This combined analysis of two clinical trials (PEDAL trial and CYCLE-HD study) aimed to (i) determine the clinical utility of body mass index (BMI) in comparison to fat tissue index (FTI) and lean tissue index (LTI) and (ii) assess the effect of a 6-month intradialytic exercise intervention compared to usual care on FTI and LTI.
Methods: A priori secondary endpoints in both trials included BMI, FTI and LTI.
Lancet
March 2025
Univ Brest, INSERM U1304-GETBO, CIC INSERM 1412, Brest, France; Centre Hospitalier Universitaire Brest, Département de Médecine Interne et Pneumologie, Brest, France; FCRIN INNOVTE Network, Saint-Etienne, France.
Background: In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has been indicated, the optimal dose is unknown. We aimed to assess efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.
Methods: RENOVE was a non-inferiority, investigator-initiated, multicentre, randomised, open-label, blinded endpoint trial done in 47 hospitals in France.
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