Objectives: A systematic characterization of the long-term sequelae after the severest form of COVID-19 requiring ECMO-therapy is lacking. Here, we present 2-year follow-up data of COVID-19 ECMO survivors, and analyze the cardiopulmonary, neurocognitive, psychological, and functional status, plus health-related quality of life (HRQL).
Methods: From 04/2020 to 09/2021, 60 COVID patients were supported with ECMO. Survival to discharge was 40.0% ( = 24), and 6-month survival was 33.3% ( = 20). Follow-ups were performed via phone and mail using validated tools. Six-month outcomes have been published before.
Results: At 2 years, 20 patients were alive. N = 19 agreed to participate in this study (median age 57.0 (45.0-63.0) years, 21.1% female). The cardiopulmonary status was satisfactory (78.9% in NYHA level I-II). Altogether, 84.2% were vastly independent in daily life. However, 47.4% still showed cognitive impairment, 21.1% moderate, 15.8% severe depression, and 15.8% posttraumatic stress disorder symptoms. HRQL subscale results were similar to 6 months, but patients self-rated their overall health significantly better (70.0% (50.0%-80.0%) vs 50.0% (30.0%-80.0%), = 0.04). The number of patients working was increasing. Social life remained markedly affected.
Conclusions: Two-year outcomes in COVID-19 ECMO patients were stable to improving as compared to 6-month results. However, long-term impairments affected all aspects of life. Long COVID specifically, and post ECMO sequelae in general need to be characterized further to enable maximum recovery.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/03913988251322710 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The influence of sodium-glucose co-transporter-2 inhibitors on the risk of cancer therapy-related cardiac dysfunction: A meta-analysis.
Biomol Biomed
March 2025
Department of Clinical Nutrition, Chongqing Jiangjin District Central Hospital/Chongqing University Affiliated Jiangjin Hospital, Chongqing, China.
Cancer therapy-related cardiac dysfunction (CTRCD) is a major concern for patients undergoing cardiotoxic cancer treatments. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have shown cardioprotective effects in both diabetic and non-diabetic populations. However, their impact on CTRCD risk remains uncertain.
View Article and Find Full Text PDFA mixed-methods study assessing the performance of a clinical decision support tool for testing for patients receiving laxatives.
Infect Control Hosp Epidemiol
March 2025
Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Objective: To better understand clinicians' rationale for ordering testing for infection (CDI) for patients receiving laxatives and the impact of the implementation of a clinical decision support (CDS) intervention.
Design: A mixed-methods, case series was performed from March 2, 2017 to December 31, 2018.
Setting: Yale New Haven Hospital, a 1,541 bed tertiary academic medical center.
Understanding Personalized Dynamics in Eating Disorders: A Dynamic Time Warp Analysis.
Int J Eat Disord
March 2025
Rivierduinen Eating Disorders Ursula, Leiden, the Netherlands.
Objective: To enhance our understanding of the processes of change and the interaction of symptoms, we applied a relatively novel method known as Dynamic Time Warp to data from low-threshold internet-based interventions directed at decreasing eating disorder (ED) symptoms and increasing help-seeking.
Method: Utilizing data from the Featback study, we examined how various factors such as ED psychopathology, binge eating, vomiting, laxative use, BMI, anxiety, depression, self-efficacy, social support, well-being, and health-related quality of life interplayed over a period of 14 months among 355 individuals at six different time points. Moreover, we explored which symptoms exerted a significant temporal relationship on others (with high out-strength) and which were most affected by other symptoms (with high in-strength).
Saying 'I'm sorry' at the bedside: when and why should apologies following medical mishaps be protected from legal liability?
Med Law Rev
January 2025
Edinburgh Law School, University of Edinburgh, Edinburgh EH8 9YL, United Kingdom.
Patients harmed by medical mishaps are often driven to litigation because of a lack of apologies and candour rather than a desire for monetary compensation. Despite attempts at clinical negligence reform, patients continue to receive unsatisfactory responses. Physicians have cited fears of legal liability as a key reason for withholding apologies.
View Article and Find Full Text PDFA clinical decision support alert to promote timely laxative use in in-patients prescribed clozapine.
BJPsych Open
March 2025
Department of Medicine, University of Otago, Christchurch, New Zealand.
Background: Clozapine-induced gastrointestinal hypomotility and constipation can result in severe and sometimes fatal gastrointestinal complications. Laxatives should be prophylactically prescribed with clozapine, but this is inconsistently achieved. Digital clinical decision support (CDS) alerts can promote safer prescribing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!