Hair health critically influences both aesthetic appearance and psychological well-being. Existing treatments often show limited efficacy and may cause side effects. (GP), known for its antioxidant and anti-inflammatory properties, has emerged as a promising botanical agent, although clinical evidence regarding its hair health benefits remains limited. This study aimed to evaluate the efficacy and safety of GP extract in improving hair parameters through a randomized controlled trial. This randomized, double-blind, placebo-controlled trial involved 100 eligible adults aged 19-60 years who were randomly allocated to either the GP or placebo group. Participants consumed 340 mL/day of the test product for 24 weeks. The primary outcomes included hair elasticity, density, diameter, glossiness, and subjective satisfaction. Safety was evaluated through laboratory tests and adverse event monitoring. After 24 weeks, the GP group showed a threefold increase in hair elasticity and density and a fourfold increase in hair diameter compared to the placebo group. The subjective satisfaction scores corroborated these findings: the GP users reported better outcomes in terms of reducing hair damage and dryness. No significant differences in hair glossiness were observed based on the instrumental and visual assessments ( > 0.05). The safety evaluations revealed no severe adverse events. All the safety evaluation metrics demonstrated no significant abnormalities. This study provides compelling evidence of the efficacy of GP extract in enhancing hair health, demonstrating both significant functional improvements and an excellent safety profile. These findings substantiate its potential as a promising functional food ingredient for comprehensive hair care interventions.
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Front Vet Sci
February 2025
Business Innovation Department, Furukawa Sangyo Kaisha, Ltd., Tokyo, Japan.
Disinfection is crucial for preventing surgical site infections. Recently, the effectiveness of sanitizers using chlorous acid (HClO) under conditions rich in organic matter has been reported, and chlorous acid water (CAW) has been approved as a food additive. This study evaluated the potential of CAW as a new presurgical disinfectant for cattle.
View Article and Find Full Text PDFNutrients
February 2025
Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.
Hair health critically influences both aesthetic appearance and psychological well-being. Existing treatments often show limited efficacy and may cause side effects. (GP), known for its antioxidant and anti-inflammatory properties, has emerged as a promising botanical agent, although clinical evidence regarding its hair health benefits remains limited.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Quebec City, QC G1J 5B3, Canada.
Hair follicle stem cells, located in the bulge region of the outer root sheath, are multipotent epithelial stem cells capable of differentiating into epidermal, sebaceous gland, and hair shaft cells. Efficient culturing of these cells is crucial for advancements in dermatology, regenerative medicine, and skin model development. This investigation aimed to develop a protocol for isolating enriched bulge-derived epithelial cells from scalp specimens to produce tissue-engineered substitutes.
View Article and Find Full Text PDFMolecules
March 2025
Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.
The leaf extract of L.f. has shown potential as a 5α-reductase inhibitor, with two bioactive markers, namely (+)-eperua-8,13-dien-15-oic acid () and (+)-eperua-7,13-dien-15-oic acid (), used for extract standardization.
View Article and Find Full Text PDFAnimals (Basel)
February 2025
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
(1) Background: Hair growth can function as an indicator of an animal's health and nutritional status, furnishing a valuable means for early diagnosis and timely modifications to management practices, and is influenced by hormones, the immune system, and the levels of minerals within the animal's body. (2) Methods: In this study, a total of 81 yaks were selected and divided into three groups according to their ages (1-2 years, 3-4 years, 5-6 years), and the concentrations of melatonin, dihydrotestosterone, IgA, IgG, and IgM in their blood serum and the levels of Ca, Mg, Zn, Fe, and P in both their blood serum and hair were detected. (3) Results: The levels of melatonin and dihydrotestosterone in yaks aged 1-2 years were significantly higher than those of other age groups ( < 0.
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