Feed additives are crucial in livestock production, enhancing performance, health, and reproductive efficiency. Recently, there has been a shift toward natural biomolecules as feed additives, specifically targeting improved reproductive outcomes and sperm quality. This transition arises from concerns about antibiotic misuse, antimicrobial resistance, and consumer preferences for eco-friendly products, along with the superior bioavailability, lower toxicity, and reduced environmental impact of natural biomolecules compared to synthetic alternatives. Collaboration among researchers, veterinarians, nutritionists, and regulators is essential to ensure safe and effective livestock management. The review explores advancements in using vital biomolecules in reproductive processes, including plant-derived bioactives such as phytochemicals and antioxidants. It investigates not only the mechanisms but also the intricate interactions of these compounds with animals' hormonal and physiological systems. Additionally, the review critically assesses challenges and prospects related to incorporating natural biomolecules into livestock practices. The potential benefits include enhanced reproductive efficiency and improved sperm quality. However, successful implementation requires understanding factors like precise dosing, potential interactions, and long-term health impacts. Overall, this comprehensive review highlights recent research, technological strides, and the future potential of integrating natural biomolecules into animal diets.
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http://dx.doi.org/10.3390/ijms26052328 | DOI Listing |
Int J Mol Sci
March 2025
Unité Transformations &Agroressources, ULR7519, Université d'Artois, UniLaSalle, F-62408 Béthune, France.
Feed additives are crucial in livestock production, enhancing performance, health, and reproductive efficiency. Recently, there has been a shift toward natural biomolecules as feed additives, specifically targeting improved reproductive outcomes and sperm quality. This transition arises from concerns about antibiotic misuse, antimicrobial resistance, and consumer preferences for eco-friendly products, along with the superior bioavailability, lower toxicity, and reduced environmental impact of natural biomolecules compared to synthetic alternatives.
View Article and Find Full Text PDFInt J Mol Sci
February 2025
Department of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, characterised by poor prognosis and limited responsiveness to chemotherapy. There is a need for new and more effective anticancer agents. Antimicrobial peptides (AMPs) represent a promising class of biomolecules for this purpose.
View Article and Find Full Text PDFSci Rep
March 2025
Center for Terahertz Waves and Key Laboratory of Optoelectronics Information and Technology (Ministry of Education), Tianjin University, Tianjin, 300072, China.
Terahertz spectroscopy has drawn great interest for the detection and characterization of biological matter, but its limited sensitivity to biomolecules with weak changes in dielectric properties with varying concentration has hinders potential bio-sensing applications. Here, a novel terahertz sensor was developed for enhancing the ability to detect biomolecules based on two electromagnetically induced transparency (EIT) metamaterials coupled with gold nanoparticles (AuNPs) integrated with biomolecules. The electrostatic interaction between AuNPs and positively charged biomolecules generates localized field enhancement at the biomolecule-metamaterial interface, resulting in a threefold increase in sensitivity for positively charged histidine that exhibit weak dielectric property changes with varying concentration.
View Article and Find Full Text PDFAnal Chem
March 2025
Department of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.
Biological aggregates play a crucial role in the pathogenesis of thrombotic diseases, especially thrombin-induced biological aggregates. Therefore, the efficient discovery of thrombin inhibitors is of great significance for the prevention and treatment of thrombotic diseases. In this study, the aggregation precursor protein fluorescent probe was successfully prepared for monitoring the production of biological aggregates induced by thrombin.
View Article and Find Full Text PDFChem Rec
March 2025
College of Chemistry & Chemical Engineering, Qingdao University, Qingdao, 266071, China.
Biomolecule-engineered metal-organic frameworks (Bio-MOFs) are designed by incorporating biomolecules into or onto MOFs through covalent and non-covalent interactions. These composite frameworks exhibit unique catalytic and biological activities, making them highly suitable for various biocatalytic applications. In this review, we highlight recent advances in the material design, bioengineering methods, structural and functional regulation techniques, and biocatalytic applications of Bio-MOFs.
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