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Proportional Versus Fixed Chest Compression Depth for Guideline-Compliant Resuscitation of Infant Asphyxial Cardiac Arrest.
Prehosp Emerg Care
October 2024
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Article Synopsis
- - The study investigates the potential for injury during chest compressions (CC) on infants and children, comparing two depth targets: 1.5 inches and 1/3 of the anterior-posterior chest diameter (APD), finding that the latter may lead to more severe injuries.
- - Using an anesthetized swine model, researchers induced asphyxia and delivered CC using both depth targets to assess the resulting injuries, with various factors being monitored and analyzed post-resuscitation.
- - Results from 36 animals showed significant differences in injury characteristics between the two compression depths, prompting further evaluation of safe guidelines for pediatric resuscitation practices.
Distinct Genomic Expression Signatures after Low-Force Electrically Induced Exercises in Persons with Spinal Cord Injury.
Int J Mol Sci
September 2024
Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.
People with a spinal cord injury are at an increased risk of metabolic dysfunction due to skeletal muscle atrophy and the transition of paralyzed muscle to a glycolytic, insulin-resistant phenotype. Providing doses of exercise through electrical muscle stimulation may provide a therapeutic intervention to help restore metabolic function for people with a spinal cord injury, but high-frequency and high-force electrically induced muscle contractions increase fracture risk for the underlying osteoporotic skeletal system. Therefore, we investigated the acute molecular responses after a session of either a 3 Hz or 1 Hz electrically induced exercise program.
View Article and Find Full Text PDFClinical effect of posterior-only approach debridement, intervertebral fusion, and internal fixation for upper thoracic tuberculosis.
Acta Orthop Traumatol Turc
August 2024
The 940th Hospital, China.
This study aimed to evaluate the effectiveness and feasibility of the posterior-only approach for debridement, interbody fusion, and internal fixation in treating upper thoracic tuberculosis. This study retrospectively analysed the clinical and radiographic data of 8 patients diagnosed with upper thoracic tuberculosis. All patients underwent posterior approach debridement, interbody fusion, and internal fixation.
View Article and Find Full Text PDFPassive bicycle training stimulates epiphyseal bone formation and restores bone integrity independent of locomotor recovery in a rat spinal cord injury model.
J Appl Physiol (1985)
September 2024
Malcom Randall Department of Veterans Affairs Medical Center, Brain Rehabilitation Research Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida, United States.
It is unknown whether activity-based physical therapy (ABPT) modalities that mobilize the paralyzed limbs improve bone integrity at the highly fracture-prone epiphyseal regions of the distal femur and proximal tibia following severe spinal cord injury (SCI). In this study, 4-mo-old skeletally mature littermate-matched male Sprague-Dawley rats received either SHAM surgery or severe contusion SCI. At 1 wk postsurgery, SCI rats were stratified to undergo no-ABPT, two 20-min bouts/day of quadrupedal bodyweight-supported treadmill training (qBWSTT), or hindlimb passive isokinetic bicycle (cycle) training, 5 days/wk for another 3 wk.
View Article and Find Full Text PDFDeveloping and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury.
ACS Nano
July 2024
Centre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Osteoporosis disrupts the fine-tuned balance between bone formation and resorption, leading to reductions in bone quantity and quality and ultimately increasing fracture risk. Prevention and treatment of osteoporotic fractures is essential for reductions in mortality, morbidity, and the economic burden, particularly considering the aging global population. Extreme bone loss that mimics time-accelerated osteoporosis develops in the paralyzed limbs following complete spinal cord injury (SCI).
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