Neurodegenerative diseases, characterised by the progressive degeneration of neurons, are a heterogeneous group of largely age-related disorders that affect millions of people worldwide [...].
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3390/ijms26051929 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prediction of dementia using CT imaging in stroke (PRODUCTS).
Eur Stroke J
March 2025
Institute of Cardiovascular and Metabolic Sciences, University of Glasgow, Glasgow, UK.
Introduction: A better understanding of who will develop dementia can inform patient care. Although MRI offers prognostic insights, access is limited globally, whereas CT-imaging is readily available in acute stroke. We explored the prognostic utility of acute CT-imaging for predicting dementia.
View Article and Find Full Text PDFControversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology.
FASEB J
March 2025
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Neuron-derived clone 77 (Nur77), a member of the orphan nuclear receptor family, is expressed and activated rapidly in response to diverse physiological and pathological stimuli. It exerts complex biological functions, including roles in the nervous system, genome integrity, cell differentiation, homeostasis, oxidative stress, autophagy, aging, and infection. Recent studies suggest that Nur77 agonists alleviate symptoms of neurodegenerative diseases, highlighting its potential as a therapeutic target in such conditions.
View Article and Find Full Text PDFProfiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.
Front Mol Neurosci
February 2025
Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, United States.
Introduction: Individuals with Down syndrome (DS) exhibit neurological deficits throughout life including the development of in Alzheimer's disease (AD) pathology and cognitive impairment. At the cellular level, dysregulation in neuronal gene expression is observed in postmortem human brain and mouse models of DS/AD. To date, RNA-sequencing (RNA-seq) analysis of hippocampal neuronal gene expression including the characterization of discrete circuit-based connectivity in DS remains a major knowledge gap.
View Article and Find Full Text PDFBackground And Aims: Alzheimer's disease (AD) is a widespread neurodegenerative condition that has a growing impact on a global scale. This study aims to examine the relationship between cerebral blood flow (CBF) and the synaptic biomarker growth-associated protein 43 (GAP-43) through the utilization of arterial spin labeling (ASL). The research identified noteworthy correlations between cerebrospinal fluid (CSF) GAP-43 levels, CBF, and cognitive composite scores, especially among participants with mild cognitive impairment (MCI) who possess the APOE-ε4 gene.
View Article and Find Full Text PDFEvaluation of gut microbiota alterations following orlistat administration in obese mice.
Front Endocrinol (Lausanne)
March 2025
Department of Endocrinology & Metabolism, Shenzhen University General Hospital, Shenzhen, China.
Background: The gut microbiota plays a pivotal role in various metabolic disorders. Orlistat has shown beneficial effects on weight loss and metabolism, but its direct impact on the gut microbiota has not been extensively reported. Thus, this study aimed to explore the effects of orlistat on the gut microbiota in mice with high-fat diet-induced obesity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!