This study primarily addresses the analytical problem of the mathematical mechanism underlying the associative impact between online searches and vaccine uptake, a relationship that has become increasingly relevant in the context of public health management. As internet search behaviors reflect public interest and sentiment, understanding their impact on vaccination trends is crucial for real-time health decision-making. A Logistic model is constructed to observe the fundamental evolutionary patterns between online searches and vaccine uptake. To explore their mutual influence, an impact function is defined, and the common structural factors with the highest fitness are determined through data fitting. Subsequently, a dynamic detection model of the associative impact between online data and societal objects, based on the mathematical mechanism, is established. Using this model, dynamic predictions are conducted to verify its predictive capability at certain stages. Through research, a symbiotic effect between online searches and vaccine uptake is identified, revealing a nonlinear correlation between the two. The model demonstrates the ability to predict vaccine uptake trends based on online search data, with certain prediction windows showing high accuracy. This research not only clarifies the mathematical mechanism underlying this relationship but also demonstrates the advantage of integrated analysis and prediction. It provides a new method for predicting online searches and vaccine uptake, offering theoretical and empirical support for public health and social science research.
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http://dx.doi.org/10.1186/s12889-025-21740-5 | DOI Listing |
Cureus
February 2025
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Colistin resistance in bacteria is a growing global issue, given its role as a critical last-resort antibiotic, particularly for treating Gram-negative bacterial infections. Pathogens adopt multiple resistance mechanisms, mediated either by plasmids or chromosomal changes. Some of the most frequently observed strategies include the occurrence of plasmid-borne mobile colistin resistance (mcr) genes, enhanced efflux pump activity, mutations in the regulatory systems, and alterations in the lipid A structure.
View Article and Find Full Text PDFAnticancer Agents Med Chem
March 2025
Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand.
Introduction: Colorectal cancer (CRC) is a type of cancer that develops due to abnormal cell growth in the colon and rectum. Existing conventional CRC treatment strategies have side effects. Hence, exploring new and advanced techniques for bacterial CRC therapy is crucial.
View Article and Find Full Text PDFFoods
February 2025
Unidad de Biotecnología Industrial, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Camino Arenero 1227, El Bajío del Arenal, Zapopan 45019, Mexico.
The fermentation of food products is a transformation and preservation process in which different metabolites are generated, contributing to consumer health. In this sense, this systematic review aims to analyze the factors that guide the perception and preference for fermented foods. In addition, different perspectives are proposed based on the findings.
View Article and Find Full Text PDFTrials
March 2025
School of Health and Wellbeing, University of Glasgow, Clarice Pears Building, 90 Byres Road, Glasgow, G12 8TB, UK.
Background: Trial attrition poses several risks for the validity of randomised controlled trials (RCTs). To better understand attrition, studies have explored and identified predictors among participant and trial characteristics. Reviews of these have so far been limited to single conditions.
View Article and Find Full Text PDFBMC Health Serv Res
March 2025
Department of Global Public Health, Karolinska Institutet, Solnavägen, 17177, Stockholm, Sweden.
Background: Mobile Health Units have become important resources for healthcare delivery to dispersed populations following natural disasters. However, criticism regarding their operational flexibility, health coverage and cost-effectiveness remain unaddressed. There are few studies evaluating their usefulness in natural disasters and deployment reports have never been included in peer-reviewed publications.
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