Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Comparison of large single and small multiple doses of cyclophosphamide exposure in mice during early prepubertal age on fertility outcome.
Sci Rep
December 2024
Centre of Excellence in Clinical Embryology, Department of Reproductive Science, Kasturba Medical College, Manipal. Manipal Academy of Higher Education, Manipal, 576 104, India.
Cyclophosphamide (CY) exposure is known to affect the ovary and impair fertility. Clinically, treatment is generally given over multiple doses, but research models have generally used single doses. The relative effects of administering multiple small doses of CY in the prepubertal period are not elucidated.
View Article and Find Full Text PDFHistopathological and Immunohistochemical Evaluation of Methotrexate-Induced Gonadal Damage in Rats: Role of SCF, mTOR, and SIRT-1.
Medeni Med J
December 2024
Erciyes University Faculty of Medicine, Histology and Embriyology, Kayseri, Türkiye.
Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use.
View Article and Find Full Text PDFZ-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation.
J Vis Exp
October 2024
Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet; Department of Cell and Molecular Biology, Uppsala University; Department of Women's and Children's Health, Uppsala University;
Women are born with a non-renewable pool of ovarian follicles, referred to as the ovarian reserve. This reserve consists of primordial follicles in the ovaries and can be affected by many factors, such as genetic and endocrine disorders, medical interventions, and endocrine disruptors. Fertility preservation is recommended when gonadotoxic treatments are necessary.
View Article and Find Full Text PDFBleomycin in vitro exposure decreases markers of human male gamete competence.
F S Sci
October 2024
Laboratory of Cell Biology, Department of Microscopy, Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto (UP), Porto, Portugal; Unit for Multidisciplinary Investigation in Biomedicine (UMIB), Laboratory for Integrative and Translational Research in Population Health (ITR), UP, Porto, Portugal; Faculty of Medicine of UP (FMUP), Porto, Portugal. Electronic address:
Article Synopsis
- - The study aimed to understand how bleomycin affects human sperm DNA integrity, function, and morphology, which could have implications for male reproductive health.
- - Sperm from 45 healthy participants was exposed to bleomycin in a controlled laboratory setting, revealing significant decreases in sperm vitality and motility, along with increased DNA fragmentation.
- - The findings indicate that bleomycin adversely affects sperm competency, potentially posing risks for male fertility, although the drug did not seem to impact reactive oxygen species levels.
Planned Immediate Chemotherapy and Cryopreservation of Oocytes or Embryos for Fertility Preservation in Women with Malignancies.
J Adolesc Young Adult Oncol
October 2024
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
Oocyte and embryo cryopreservation before gonadotoxic treatment are established methods to increase the likelihood of live births. Although several sociodemographic factors were found to be associated with undergoing fertility preservation (FP) treatment, clinical characteristics such as planned immediate chemotherapy were not fully investigated. We aimed to investigate whether the planned immediate chemotherapy is related to the decision to undergo oocyte/embryo cryopreservation for FP with adjustment for other clinical characteristics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!