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Association between driving pressure-guided ventilation and postoperative pulmonary complications in surgical patients: dealing with zero-events in evidence synthesis. Comment on Br J Anaesth 2024; 133: 647-57.
Br J Anaesth
March 2025
Department of Surgical Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China; Central Laboratory, The Fourth Affiliated Hospital of China Medical University, Shenyang, China. Electronic address:
Integrating Genomic, Transcriptomic, and Phenotypic information to Explore Drug Resistance in Mycobacterium tuberculosis sub-lineage 4.2.2.2.
J Appl Microbiol
March 2025
Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, P.O.Box 9086, Addis Ababa, Ethiopia.
Aims: Mycobacterium tuberculosis (Mtb) remains a major global health challenge, particularly due to increasing drug resistance. Beyond the well-characterized mutations, the mechanisms involved in driving resistance appear to be more complex. This study investigated the differential gene expression of Ethiopian drug-resistant Mtb sub-lineage 4.
View Article and Find Full Text PDFOptimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments.
J Med Chem
March 2025
EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, Scotland EH9 3FJ, U.K.
Cyclophilins have been implicated in the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH). Pharmacological inhibition of the cyclophilin B isoform has the potential to attenuate liver fibrosis in MASH, but current cyclophilin inhibitors in clinical trials lack isoform selectivity. We previously reported the novel tri-vector small-molecule inhibitor that exhibited improved subtype selectivity by simultaneously engaging three pockets on the surface of cyclophilins.
View Article and Find Full Text PDFModeling the impact of between-lot and within-lot variability in Listeria monocytogenes contamination on risk reduction from sampling ready-to-eat foods.
J Food Prot
March 2025
Human Foods Program, U.S. Food and Drug Administration, 5001 Campus Drive, College Park, MD 20740 USA.
Microbiological sampling and testing are widely utilized in food safety risk management. We developed risk assessments to quantify the impact of various sampling plans on the risk of invasive listeriosis to consumers. We used the FDA-iRISK® tool and adapted available process, consumption, and dose response modules of published L.
View Article and Find Full Text PDFEpidemiology, Phylogeny and Genetic Characterization of Carbapenem-resistant Citrobacter spp. from 5 hospitals in China.
J Glob Antimicrob Resist
March 2025
Department of Laboratory Medicine, The First Medicine Center of Chinese PLA General Hospital, Beijing 100853, China. Electronic address:
Objectives: Carbapenem-resistant Citrobacter spp. (CRC) are increasingly recognized as healthcare-associated pathogens, while systematic studies on clinical epidemiology, genetic diversity, and resistant mechanisms of CRC are relatively scarce. The present study provides comprehensive and systematic research on CRC.
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