Rationale And Objectives: The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).
Materials And Methods: The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies. Bivariate random effects models were utilized to compute the sensitivity and specificity of 68Ga-FAPI PET CT/MR in OC. The I-square index (I) was utilized to measure heterogeneity and sensitivity analysis were employed to test it.
Results: The pooled sensitivity as well as specificity for 68Ga-FAPI PET CT/MR in OC were 0.90 (95% CI: 0.84-0.95) as well as 0.95 (95% CI: 0.91-0.97), correspondingly. In the subanalysis for metastatic lesions (lymph node [LN] metastases and peritoneal involvement), the pooled sensitivity and specificity of 68Ga-FAPI PET CT/MR were 0.94 (95% CI: 0.74-0.99) and 0.95 (95% CI: 0.84-0.99) for identifying metastatic LNs as well as 0.93 (95% CI: 0.81-0.97) and 0.96 (95% CI: 0.89-0.99) about peritoneal carcinomatosis evaluation, correspondingly. In the head-to-head comparison with 18F-FDG PET/CT, 68Ga-FAPI PET CT/MR exhibited a better sensitivity in identifying peritoneal metastases (P=.0004).
Conclusion: 68Ga-FAPI PET CT/MR displayed a high overall diagnostic effectiveness in OC. When evaluating metastatic peritoneal lesions of OC, 68Ga-FAPI PET CT/MR displayed a superior pooled sensitivity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.acra.2025.02.040 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Meta-analysis of 68Ga-FAPI PET in Assessment of Ovarian Cancer.
Acad Radiol
March 2025
Department of Nuclear Medicine, Beijing Luhe Hospital, Capital Medical University, Xinhua Road 82, Tong Zhou District, 101199 Beijing, China.
Rationale And Objectives: The objective of this research is to carry out a systematic review and meta-analysis to detect the diagnostic efficacy of 68Ga-FAPI Positron Emission Tomography (PET) Computed Tomography/Magnetic Resonance (CT/MR) in total of the lesions as well as different aspects of metastasis in individuals with ovarian cancers (OC).
Materials And Methods: The PubMed, Embase, Cochrane library, and Web of Science databases were thoroughly searched until the cut-off date of July 23, 2024. The assessment of 68Ga-FAPI PET CT/MR of OC was presented by the included studies.
Utilization of Gallium-68 Fibroblast Activation Protein Inhibitor Positron Emission Tomography (⁶⁸Ga-FAPI PET) for Head and Neck Malignancies With Neck Imaging Reporting and Data System (Ni-RADS) Correlation.
Cureus
February 2025
Department of Radiodiagnosis, Sri Devaraj Urs Medical College, Kolar, IND.
Background Head and neck cancers (HNCs) encompass a group of malignancies that arise in the mucosal surfaces of the oral cavity, pharynx, larynx, and other related structures. Advances in imaging modalities such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) have improved tumor detection and staging, aiding in personalized treatment approaches. PET-CT is used to diagnose and stage various cancers.
View Article and Find Full Text PDFPrimary Renal Neuroendocrine Tumor Demonstrated on 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT.
Clin Nucl Med
March 2025
Department of Nuclear Medicine, West China Hospital of Sichuan University.
Primary renal neuroendocrine tumors are very rare. Herein, we report a case of imaging findings of a renal neuroendocrine tumor in a 36-year-old man. On 68Ga-FAPI-04 PET/CT and 18F-FDG PET/CT, it presented as a renal soft tissue mass with intense FAPI uptake (SUVmax: 20.
View Article and Find Full Text PDFDifferences in Fibroinflammatory Activity Shown on Ga-FAPI-04 and F-FDG PET/CT in the Two Subtypes of IgG4-Related Disease.
J Nucl Med
March 2025
Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China;
IgG4-related disease (IgG4-RD) is a highly heterogeneous autoimmune disease. Recently, 2 subtypes of IgG4-RD, proliferative and fibrotic, were defined according to patients' clinicopathologic characteristics. The purpose of this study was to determine the difference in fibroinflammatory activity shown on Ga-FAPI-04 and F-FDG PET/CT in the proliferative and fibrotic IgG4-RD subtypes.
View Article and Find Full Text PDF18F-FDG PET/CT Identified Rectal Malignancy Earlier Than 68Ga-FAPI PET/CT.
Clin Nucl Med
March 2025
Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
A 69-year-old man with esophageal cancer underwent dual-tracer PET/CT using 18F-FDG and 68Ga-FAPI during his treatment. At baseline, neither scan showed abnormal uptake in the rectum. Three months later, an interim 18F-FDG PET/CT revealed focal uptake in the rectum, while the 68Ga-FAPI PET/CT showed no abnormal findings.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!