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Mechanism of Conformational Selection of tRNA by Bacterial Deaminase TadA.
Biochemistry
March 2025
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Base editing is a common mechanism by which organisms expand their genetic repertoire to access new functions. Here, we explore the mechanism of tRNA recognition in the bacterial deaminase TadA, which exclusively recognizes tRNA and converts the wobble base adenosine (A34) to inosine. We quantitatively evaluate the dynamics of tRNA binding by incorporating the fluorescent adenine analogue 2-aminopurine (2-AP) at position 34 in the wobble base of the anticodon loop.
View Article and Find Full Text PDFHealth literacy in adults with a spinal cord injury or disorder: An updated and expanded systematic review.
Disabil Health J
March 2025
School of Psychology, The University of Adelaide, SA, 5000, Australia.
Background: The importance of health literacy in personal health management is widely recognised in the general population, yet remains poorly understood in some patient groups, including people with spinal cord injury or disorder (SCI/D).
Objectives: The systematic review had two objectives: (1) to determine the health literacy levels of individuals with SCI/D, and (2) to identify facilitators and barriers to developing health literacy in this group.
Methods: Seven databases (CINAHL, Embase, Emcare, ProQuest, PsycINFO, PubMed, and Web of Science) were searched from inception, with an updated search completed on January 21, 2025.
Recognizing the role of fibromyalgia in post-exertional malaise.
Trends Endocrinol Metab
March 2025
Rheumatology Unit, Department of Medicine - DIMED, University and Hospital of Padova, Padova, Italy.
Physician assessment, comparative abilities and artificial intelligence: implications for informed consent.
J Med Ethics
March 2025
Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
While artificial intelligence's (AI's) potential role in enhancing diagnostic accuracy and personalising treatment is well-recognised, its application in evaluating physicians raises critical ethical concerns as well. The paper examines the impact of AI on the 'comparative abilities' exception to informed consent, which currently exempts physicians from disclosing information about the performance of other providers. With AI's ability to generate granular, accurate comparisons of physician metrics, this exception will be challenged, potentially empowering patients to make more informed decisions.
View Article and Find Full Text PDFLarge language models for surgical informed consent: an ethical perspective on simulated empathy.
J Med Ethics
March 2025
Institute for Ethics, History and Philosophy of Medicine, Hannover Medical School, Hannover, Germany.
Informed consent in surgical settings requires not only the accurate communication of medical information but also the establishment of trust through empathic engagement. The use of large language models (LLMs) offers a novel opportunity to enhance the informed consent process by combining advanced information retrieval capabilities with simulated emotional responsiveness. However, the ethical implications of simulated empathy raise concerns about patient autonomy, trust and transparency.
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