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Transforming rapid response team through artificial intelligence.
Acute Crit Care
February 2025
Division of Pulmonary, and Critical Care Medicine, Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration.
Physiol Rev
March 2025
Institut Pasteur, Université Paris Cité, CNRS UMR 3691, Membrane Traffic and Pathogenesis, Paris, France.
Tunneling nanotubes (TNTs) are thin tubular membrane protrusions that connect distant cells, generating a complex cellular network. Over the past few decades, research on TNTs has provided important insights into their biology, including structural composition, formation mechanisms, modulators, and functionality. It has been discovered that TNTs allow cytoplasmic continuity between connected cells, facilitating fast intercellular communication via both passive or active exchange of materials.
View Article and Find Full Text PDFSynergizing adaptive immunity and regenerative signals to enhance osteochondral defects repair.
Bioact Mater
April 2025
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
In clinical practice, repairing osteochondral defects (OCDs) is challenging because of the complex cartilage/subchondral bone structure and intricate immunological microenvironment. Here, we identify the crucial role of adaptive immunity dysfunction by revealing that an increase of T helper 17 (Th17) cells exacerbated osteochondral tissue degradation via its pro-inflammatory cytokine interleukin-17 (IL-17) in the early-stage OCDs. Next, we leveraged this adaptive immunity mechanism and combined it with regenerative signals to develop a multifunctional hydrogel system capable of simultaneously tackling immune dysfunction and regenerative deficiency.
View Article and Find Full Text PDFClinical outcome and peripheral CD4 T profile in impending myasthenic crisis: A prospective cohort study.
J Neuroimmunol
March 2025
Huashan Rare Disease Center and Department of Neurology, Huashan Hospital Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai 200040, China. Electronic address:
Impending Myasthenic Crisis (MC) is defined as a rapid worsening of myasthenia gravis (MG) that can progress to respiratory failure within days to weeks. The clinical data regarding the outcome and peripheral immune profile is limited. This multicenter cohort enrolled 37 patients with impending MC who were given timely rescue therapies from six university hospitals (n = 272).
View Article and Find Full Text PDFThe impact of urban parks on the thermal environment of built-up areas and an optimization method.
PLoS One
March 2025
Department of Architecture, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Rapid urbanization, while transforming people's living environments, also brings a series of urban issues such as the urban heat island effect. The urban park is an effective means to alleviate the urban heat island effect in summer. How to make better use of the cold island effect formed by urban parks to improve the urban outdoor thermal environment is an important topic.
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