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Phosphodiesterase Inhibitor Therapy in Pulmonary Hypertension-Associated COPD: Revisiting an Old Controversy With Renewed Interest.
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Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Caffeine-clarithromycin coadministration and hyperlactatemia in a young infant: a case report.
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Division of Critical Care Medicine, Department of Pediatrics, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo - São Paulo (SP), Brazil.
Apnea is a major complication of acute respiratory tract infection in young infants and may lead to the need for ventilatory support. Caffeine is methylxanthine, which is considered the mainstay of pharmacologic treatment for apnea of prematurity. On the basis of neonatal guidelines, caffeine has been used as a respiratory stimulant for the treatment of acute respiratory tract infection-related apnea, despite low evidence of its ability to improve clinical outcomes.
View Article and Find Full Text PDFPhosphodiesterase 10A Inhibitor Modulates Right Ventricular Outflow Tract Electrophysiological Activities and Calcium Homeostasis via the cGMP/PKG Pathway.
J Cell Mol Med
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Fu Jen Catholic University, School of Medicine, New Taipei City, Taiwan.
Phosphodiesterase inhibitors regulate intracellular Ca of cardiomyocytes through enhancing second messenger signalling. This study aimed to investigate whether TP-10, a selective phosphodiesterase10A inhibitor, modulates Ca cycling, attenuating arrhythmogenesis in the right ventricular outflow tract (RVOT). Right ventricular tissues from New Zealand white rabbits were harvested, and electromechanical analyses of ventricular tissues were conducted.
View Article and Find Full Text PDFComparison of PDE-5 inhibitors used in erectile dysfunction with some candidate molecules: A study involving molecular docking, ADMET, DFT, biological target, and activity.
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Energy Systems Engineering Department, Engineering Faculty, Adana Alparslan Türkeş Science and Technology University, Adana, 01250, Türkiye.
Erectile dysfunction (ED) is a urological condition defined as the inability of a man to achieve or maintain an erection. This condition negatively affects his sexual performance and the performance of his partner. Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat ED.
View Article and Find Full Text PDFChronic Hand Eczema (CHE): A Narrative Review.
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Dermatology Unit, IRCCS Humanitas Research Hospital, Rozzano, MI, Italy.
Chronic hand eczema (CHE) is a common and challenging skin condition, characterized by persistent hand dermatitis which lasts over 3 months or recurs at least twice a year. This condition is often multifactorial, involving genetic predispositions, environmental factors and triggers, such as irritants and allergens. Studies show a higher incidence in women, though prevalence estimates vary across different age groups.
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