Background: Higher daily step counts is associated with reduced risk of many chronic diseases. Increased physical activity improves asthma outcomes. There are no known prevention strategies for adult incident asthma.
Objective: To determine whether objective physical activity impacts adult asthma incidence.
Methods: Participants in the All of Us Research Program retrospective cohort aged ≥ 18 years with linked personal activity tracker and electronic health record data met inclusion. Asthma was defined as two ICD-9/10 codes and ≥ 1 medication. Participants with an asthma diagnosis date before/within six months of activity monitor initiation were assigned prevalent asthma; participants diagnosed after six months of activity monitoring were assigned incident asthma.
Results: 8,360 participants met inclusion. Median average steps/day were higher among asthma-free participants [7,795 (5,879-9,921, 95% CI), n = 7,700] than participants with prevalent [6,968 (5,036-9,014, 95% CI), n = 450] or incident asthma [6,953 (5,215-8,261), n = 210] (p < 0.0001). Significant time by incident asthma interaction was observed with a greater decline in steps/day over time in the incident asthma cohort (p = 0.018). An inverse relationship was observed between average steps/day and asthma incidence after adjusting for age, sex, race, body mass index, major depressive disorder, sleep apnea, and chronic obstructive lung disease [adjusted hazard ratio 0.93 (0.88-0.98, 95% CI) per 1,000 average daily step increase].
Conclusions: Objectively measured daily steps are lower in adults who develop incident asthma and may represent a modifiable risk factor to reduce asthma incidence. Future studies should objectively monitor physical activity among adults at risk for and with asthma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaci.2025.02.033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of clinical benefits and economic value of weight loss in a Swedish population using a simulation model.
Obesity (Silver Spring)
March 2025
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Objective: The objective of this study was to estimate the 10-year clinical benefits and economic value of weight loss in a Swedish population with obesity using a value of weight-loss simulation model.
Methods: Data on the prevalence of and costs associated with obesity and obesity-related complications (ORCs) were applied within an adapted simulation model to evaluate weight-loss benefits for a 2023 Swedish population over 10 years. The 10-year incidence of 10 ORCs and treatment costs in a random cohort of 10,000 individuals were estimated for a stable weight scenario and four weight-loss (5%-20%) scenarios.
Evaluating the Efficacy of Premedication in Preventing Hypersensitivity Reactions to Nonionic Contrast Agents.
Biol Pharm Bull
March 2025
Division of Drug Informatics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo 105-8512, Japan.
Iodine-based contrast agents can induce various acute hypersensitivity reactions ranging from mild itching or vomiting shortly after administration to severe hypotension or loss of consciousness. In Japan, steroid premedication is commonly used to prevent acute hypersensitivity reactions. However, little clear evidence supporting its efficacy is available.
View Article and Find Full Text PDFAssociation of Daily Steps Over Time with Adult Asthma Incidence.
J Allergy Clin Immunol
March 2025
Department of Medicine, Vanderbilt University Medical Center, 1161 21(st) Avenue South, Nashville, TN 37232, USA. Electronic address:
Background: Higher daily step counts is associated with reduced risk of many chronic diseases. Increased physical activity improves asthma outcomes. There are no known prevention strategies for adult incident asthma.
View Article and Find Full Text PDFClimate Change and Allergens: Current and Future Impacts.
J Allergy Clin Immunol Pract
March 2025
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. Electronic address:
Climate change will continue to impact allergic diseases in direct and indirect ways. Rising global temperatures are contributing to increased duration of pollen seasons, altered aeroallergen production and potency of allergens, and changes in the geographic distribution of allergenic plants that drive increased human exposure to aeroallergens and increased allergic disease morbidity. Climate change is inextricably linked with air pollution, the latter of which was shown to act as an adjuvant for allergic inflammatory processes promoting allergic sensitization.
View Article and Find Full Text PDFWhat the clinician should know when ordering a mast cell tryptase test: A review article for the North American practicing clinician.
Ann Allergy Asthma Immunol
March 2025
University Hospital of Reims, Immunology Laboratory, Biology and Pathology Department, Reims, France; University of Reims Champagne-Ardenne, INSERM UMR 1250, Reims, France. Electronic address:
Tryptase is currently the most specific mast cell biomarker available in clinical laboratories. Tryptase levels in peripheral blood contribute to the diagnostic, prognostic and therapeutic evaluation of three clinical categories: (1) immediate hypersensitivity reactions including the life-threatening systemic form known as anaphylaxis, (2) clonal mast cell diseases and other myeloid malignancies, including as a biomarker for efficacy of chemotherapeutic agents targeting mast cell survival, and (3) hereditary α-tryptasemia (HαT), a genetic trait found in 4 - 8% of general population associated to increased risk of severe immediate hypersensitivity reactions. Rapidly evolving pathophysiology knowledge and management guidelines impact tryptase use in clinical practice, explaining the need for frequent updates.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!