Drug discovery is a collaborative endeavor that often involves scientists from various disciplines and global collaborators. Efficient real-time sharing and updating of design-make-test-analyze (DMTA) information remains a challenge in drug discovery, hindering timely decision-making and project advancement. We propose a novel approach utilizing existing electronic inventory systems as DMTA workflow tracking platforms. Our approach at Sygnature Discovery leverages the inherent flexibility of these systems, allowing us to tailor stages and compound information to individual project needs, resulting in significant cost savings compared with building an in-house solution or purchasing a commercial solution. Given the wide adoption of electronic inventory platforms in drug discovery, our strategy holds immense potential for easy adoption and broad application across the industry.
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http://dx.doi.org/10.1016/j.slast.2025.100262 | DOI Listing |
J Prev Alzheimers Dis
March 2025
Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry/Hubei Province of China for Neurological Disorders Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: The swift rise in the prevalence of Alzheimer's disease (AD) alongside its significant societal and economic impact has created a pressing demand for effective interventions and treatments. However, there are no available treatments that can modify the progression of the disease.
Methods: Eight AD brain tissues datasets and three blood datasets were obtained.
J Genet Eng Biotechnol
March 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Background: Cancer remains an awful challenge, despite years of targeting proteins to control its relentless growth and spread. Fungal metabolites, a treasure of natural chemicals, offer a glimmer of hope. Telomeres, the cellular "caps," are a focal point in cancer research.
View Article and Find Full Text PDFFree Radic Biol Med
March 2025
Department of Radiation Oncology, Mays Cancer Center at UT Health San Antonio MD Anderson, Joe R. and Teresa Lozano Long School of Medicine, UT Health San Antonio, TX, USA; Barshop Institute for Longevity and Aging Studies at UT Health San Antonio, TX, USA. Electronic address:
Acetyl-CoA Synthetase Short Chain Family Member-1 (ACSS1) catalyzes the ligation of acetate and coenzyme A to generate acetyl-CoA in the mitochondria to produce ATP through the tricarboxylic acid (TCA) cycle. We recently generated an ACSS1-acetylation (Ac) mimic knock-in mouse, where lysine 635 was mutated to glutamine (K635Q), which structurally and biochemically mimics an acetylated lysine. ACSS1 enzymatic activity is regulated, at least in part, through the acetylation of lysine 635 in mice (lysine 642 in humans), a Sirtuin 3 deacetylation target.
View Article and Find Full Text PDFFitoterapia
March 2025
Innovative Practice Platform for Research-oriented Teaching of Natural Product Resources Development and Application, School of Food Science and Chemical Engineering, Zhengzhou University of Technology, Zhengzhou, Henan 450044, China.
A series of novel amide-fused isosteviol derivatives were designed and synthesized. Their cytotoxicities in vitro against HCT-116 cells were screened. The preliminary bioassays indicated that most of the title compounds exhibited noteworthy cytotoxicity.
View Article and Find Full Text PDFSLAS Technol
March 2025
Sygnature Discovery Ltd., BioCity, Pennyfoot Street, Nottingham, United Kingdom.
Drug discovery is a collaborative endeavor that often involves scientists from various disciplines and global collaborators. Efficient real-time sharing and updating of design-make-test-analyze (DMTA) information remains a challenge in drug discovery, hindering timely decision-making and project advancement. We propose a novel approach utilizing existing electronic inventory systems as DMTA workflow tracking platforms.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!