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Fecal microbiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome.
J Microbiol Immunol Infect
March 2025
Chang Gung Microbiota Therapy Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:
Background: Clostridium innocuum is a vancomycin-resistant pathobiome associated with poor clinical outcomes in inflammatory bowel disease (IBD). In ulcerative colitis (UC), it correlates with reduced remission rates, while in Crohn's disease (CD), it is linked to creeping fat formation and intestinal strictures. Notably, some patients experience refractory or recurrent C.
View Article and Find Full Text PDFAI-driven Personalized Medicine: Transforming Clinical Practice in Inflammatory Bowel Disease.
Gastroenterology
March 2025
APC Microbiome Ireland, College of Medicine and Health, University College Cork, Cork, Ireland.
Inflammatory bowel disease (IBD) is marked by significant clinical heterogeneity, posing challenges for accurate diagnosis and personalized treatment strategies. Conventional approaches, such as endoscopy and histology, often fail to adequately and accurately predict medium and long-term outcomes, leading to suboptimal patient management. Artificial intelligence (AI) is emerging as a transformative force enabling standardized, accurate, and timely disease assessment and outcome prediction, including therapeutic response.
View Article and Find Full Text PDFSurvival and parenteral nutrition dependence in patients aged 65 and older with short bowel syndrome: a retrospective observational cohort study.
Am J Clin Nutr
March 2025
Assistance Publique-Hôpitaux de Paris (AP-HP), Department of Gastroenterology, IBD and Intestinal Failure, Beaujon Hospital, Clichy, France. Electronic address:
Background: Home parenteral support (PS) is the standard treatment for chronic intestinal failure (CIF) with short bowel syndrome (SBS) as the leading cause. However, outcomes of PS in older patients remain poorly studied.
Methods: This retrospective observational study evaluated patients newly diagnosed with SBS-CIF initiating PS between 2015 and 2020 at a national French CIF referral center.
Outcomes of Intestinal Transplantation for Familial Adenomatous Polyposis Associated Intraabdominal Desmoid Disease.
J Gastrointest Surg
March 2025
Department of Colorectal Surgery; Digestive Disease Institute, Cleveland Clinic, Ohio, USA; The Sanford R. Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Ohio, USA. Electronic address:
Mucosal advancement flap versus ligation of the inter-sphincteric fistula tract for management of trans-sphincteric perianal fistulas in the elderly: a retrospective study.
Int J Colorectal Dis
March 2025
Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Purpose: There is no consensus on the standard approach for trans-sphincteric perianal fistulas (TPAF) in the elderly population. The most commonly used sphincter-saving procedures are ligation of the inter-sphincteric fistula tract (LIFT) and mucosal advancement flap (MAF). We aimed to evaluate the incidence and risk factors for recurrence and incontinence in elderly patients with TPAF using both approaches.
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