MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. miR-34 is a highly conserved miRNA during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity. To have a more comprehensive understanding of miR-34, this paper reviewed the functional evolution of miR-34, and provided a reference for further research on the related functions of miR-34.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.abb.2025.110382 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
microRNA-34: A multifunctional miRNA family.
Arch Biochem Biophys
March 2025
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China. Electronic address:
MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. miR-34 is a highly conserved miRNA during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity.
View Article and Find Full Text PDFThe role of miR-16 and miR-34a family in the regulation of cancers: A review.
Heliyon
February 2025
Department of Anatomical Sciences and Reproductive Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
microRNAs (miRNAs), regulatory non-coding RNAs, can change translation, and decrease protein expression. miR-16 and miR-34a families are among the most abundant tumor suppressors and highly conserved microRNAs recognized. They have vital regulatory roles in health and disease.
View Article and Find Full Text PDFmiR-34-5p, a potential RNA biopesticide for controlling Spodoptera frugiperda by targeting of SfEcR and SfE74.
Pestic Biochem Physiol
March 2025
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi Key Laboratory of Biotechnology, Institute of Biotechnology, Shanxi University, Taiyuan, China. Electronic address:
Spodoptera frugiperda is an agricultural pest with strong adaptability and migration ability. For decades, chemical control has been an important technical measure for controlling S. frugiperda.
View Article and Find Full Text PDFRole of the p53/miR-34a/SIRT1 Feedback Loop in Metformin-induced Radiosensitivity of Colorectal Cancer Cells.
Curr Radiopharm
February 2025
Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Introduction: Metformin induces radiation sensitivity in cancer cells, including colorectal cancer cells; however, the exact molecular mechanisms underlying its radiosensitive effects are not yet known. In this study, we investigated the role of the p53/miR-34a/SIRT1 pathway in the radiosensitivity of colon cancer cells.
Methods: The study was carried out from 2020 to 2022 at the Qazvin University of Medical Science's Cellular and Molecular Research Center.
Genome-Wide microRNA Expression Profiling in Human Spermatozoa and Its Relation to Sperm Quality.
Genes (Basel)
January 2025
Institute for Regenerative Medicine and Biotherapy (IRMB), University of Montpellier, INSERM, CHU Montpellier, 34295 Montpellier, France.
Background: Sperm samples are separated into bad and good quality samples in function of their phenotype, but this does not indicate their genetic quality.
Methods: Here, we used GeneChip miRNA arrays to analyze microRNA expression in ten semen samples selected based on high-magnification morphology (score 6 vs. score 0) to identify miRNAs linked to sperm phenotype.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!