Objectives: To analyze the marginal/internal gap and the fatigue behavior of crowns made of two different materials, using four combinations of a digital workflow-two intraoral scanners (IOSs) and two milling machines.
Materials And Methods: Crowns were made considering three factors: IOS (a confocal microscopy-based scanner: TRIOS 3-TR; or a combination of active triangulation and dynamic confocal microscopy: Primescan-PS), milling machines (four-axis: CEREC MC XL-CR or five-axis: PrograMill PM7-PM), and restorative material (lithium disilicate-LD or resin composite-RC) ( = 10). The bonding surface of each crown was treated and bonded to each respective glass fiber-reinforced epoxy resin die using a dual-cure resin cement. A computed microtomography analysis was performed to access marginal/internal gap. The specimens were subjected to a cyclic fatigue test (20 Hz, initial load = 100 N/5,000 cycles; step size= 50 N/10,000 cycles until 1,500 N, then if specimens survived, the step size was increased to 100 N/10,000 cycles).
Statistical Analysis: For data analysis, three-way analysis of variance and Kaplan-Meier with log-rank (Mantel-Cox) test were performed (α = 0.05).
Results: TR resulted in a smaller axial-occlusal angle and occlusal gap, and five-axis milling resulted in a smaller marginal gap, axial-occlusal angle, and occlusal gap. Angled points and occlusal surface showed a tendency for overmilling. RC crowns displayed higher survival rates and a more pronounced topography compared with LD independently of the scanning and milling method. LD crowns produced with a five-axis milling machine resulted in higher fatigue performance and rougher topography compared with a four-axis machine.
Conclusion: RC crowns displayed better fatigue behavior compared with LD, while LD benefited from a five-axis machine for improved survival probability.
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http://dx.doi.org/10.1055/s-0044-1791705 | DOI Listing |
Ann Med
December 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Despite the high prevalence of mental stress among physicians, reliable screening tools are scarce. This study aimed to evaluate the capability of the Physician Well-Being Index (PWBI) in identifying distress and adverse consequences among Chinese physicians.
Methods: This cross-sectional online survey recruited 2803 physicians from Southern Mainland China snowball sampling between October and December 2020.
Eur J Dent
March 2025
Post-Graduate Program in Oral Sciences (Prosthodontics Units), Faculty of Dentistry, Universidade Federal de Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.
Objectives: To analyze the marginal/internal gap and the fatigue behavior of crowns made of two different materials, using four combinations of a digital workflow-two intraoral scanners (IOSs) and two milling machines.
Materials And Methods: Crowns were made considering three factors: IOS (a confocal microscopy-based scanner: TRIOS 3-TR; or a combination of active triangulation and dynamic confocal microscopy: Primescan-PS), milling machines (four-axis: CEREC MC XL-CR or five-axis: PrograMill PM7-PM), and restorative material (lithium disilicate-LD or resin composite-RC) ( = 10). The bonding surface of each crown was treated and bonded to each respective glass fiber-reinforced epoxy resin die using a dual-cure resin cement.
Eur J Dent
March 2025
Department of Dental Materials Science, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, North Holland, the Netherlands.
Objectives: This article evaluates the marginal and internal gap, interfacial volume, and fatigue behavior in computer-aided design-computer-aided manufacturing (CAD-CAM) restorations with different designs (crowns or endocrowns) made from lithium disilicate-based ceramic (LD, IPS e.max CAD, Ivoclar AG) or resin composite (RC, Tetric CAD, Ivoclar AG).
Materials And Methods: Simplified LD and RC crowns (-C) and endocrowns (-E) were produced ( = 10) using CAD-CAM technology, through scanning (CEREC Primescan, Dentsply Sirona) and milling (CEREC MC XL, Dentsply Sirona), and then adhesively bonded to fiberglass-reinforced epoxy resin.
Drug Alcohol Depend
March 2025
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA. Electronic address:
Background: Little is known about acute subjective and physiological responses to alcohol in individuals with alcohol use disorder (AUD), particularly as it pertains to the spectrum of AUD severity. This study examined acute biphasic alcohol response phenotypes in participants with mild, moderate, and severe AUD.
Methods: Study data was from the third cohort of the Chicago Social Drinking Project (N = 101, 50 % male; M age=27.
Mult Scler Relat Disord
March 2025
Faculty of Information Technology and Electrical Engineering, University of Oulu, Oulu, Finland. Electronic address:
Background: Fatigue is the most debilitating and prevalent symptom of multiple sclerosis (MS), affecting up to 80 % of patients and significantly impairing quality of life (QoL). Managing MS fatigue is challenging due to its multifactorial nature, encompassing physical, cognitive, and psychosocial components. Mobile health (mHealth) tools offer promising approaches for self-management, but most lack personalization and rigorous validation.
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