In vitro fertilization, cryopreservation and pre-implantation genetic testing are transformative reproductive technologies offering hope for individuals facing fertility challenges. Scientifically, understanding the science of developmental biology is essential for comprehending the mechanisms and implications of these technologies. In embryological sciences, biological perspectives identify life as a series of developmental stages ranging from conception to viability, each potentially representing a different 'beginning' of life. However, the concept of ensoulment, rooted in religious and cultural beliefs, introduces a speculative dimension ultimately influencing how legal systems worldwide define and protect human life in the context of reproductive decision-making. Legally, high-profile cases such as 'Sofia Vergara v. Nick Loeb' or 'Quintavalle v. Human Fertilization and Embryology Authority' raise questions about both parental and fetal reproductive rights and consent. This paper highlights the importance of a multidisciplinary approach in developmental biology education for responsible and equitable practices of reproductive technologies. It underscores the importance of incorporating these considerations into the classroom teaching as case study discussions aligned with the DEI approach, to better equip students for the controversies they may encounter in their roles of developmental biologists.
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http://dx.doi.org/10.1016/j.ydbio.2025.03.005 | DOI Listing |
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January 2025
Center for Complex Biological Systems, University of California, Irvine, Irvine, California, USA.
The delivery of intracellular cargoes by kinesins is modulated at scales ranging from the geometry of the microtubule networks down to interactions with individual tubulins and their code. The complexity of the tubulin code and the difficulty in directly observing motor-tubulin interactions have hindered progress in pinpointing the precise mechanisms by which kinesin's function is modulated. As one such example, past experiments show that cleaving tubulin C-terminal tails (CTTs) lowers kinesin-1's processivity and velocity on microtubules, but how these CTTs intertwine with kinesin's processive cycle remains unclear.
View Article and Find Full Text PDFGenome Res
March 2025
Department of Microbiology and Molecular Genetics, University of California, Davis, California 95616, USA;
As transposable elements (TEs) coevolved with the host genome, the host genome exploited TEs as functional regulatory elements of gene expression. Here we show that a subset of KRAB domain-containing zinc-finger proteins (KZFPs), which are highly expressed in mitotically dividing spermatogonia, repress the enhancer function of endogenous retroviruses (ERVs) and that the release from KZFP-mediated repression allows activation of ERV enhancers upon entry into meiosis. This regulatory feature is observed for independently evolved KZFPs and ERVs in mice and humans, suggesting evolutionary conservation in mammals.
View Article and Find Full Text PDFCells Dev
March 2025
Laboratory of Morphogenesis, The Rockefeller University, New York, NY 10065, United States of America. Electronic address:
The dominant approach to the study of living systems in the 20th century into today has been that of a reductionist approach focused on genetics and biochemistry. The hunt for genes and the elucidation of their biochemical outputs has organized funding in research, educational curricula, academic promotion, and the distribution of prestige through awards. Such reductionism has gone hand in hand with an ontology of the machine.
View Article and Find Full Text PDFN Biotechnol
March 2025
The Mina & Everard Goodman Faculty of Life Sciences and the Institute for Nanotechnology and Advanced Materials, Bar Ilan University, Ramat-Gan, Israel. Electronic address:
While biomarker-guided treatments and NGS-based approaches are refining precision medicine, they are not universally applicable. The gap between the genomic characterization of tumors and their functional behavior is becoming increasingly evident. There is an escalating demand for functional assays that can customize cancer treatments for individual patients and bridge this gap.
View Article and Find Full Text PDFJ Biol Chem
March 2025
Department of Cellular and Developmental Biology, Department of Surgery, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:
Pyruvate dehydrogenase kinase (PDK) 1 is one of four isozymes that inhibit the oxidative decarboxylation of pyruvate to acetyl-CoA via pyruvate dehydrogenase. PDK activity is elevated in fasting or starvation conditions to conserve carbohydrate reserves. PDK has also been shown to increase mitochondrial fatty acid utilization.
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