A 50-year-old female presented with abdominal pain. Upper gastrointestinal endoscopy revealed a 30 mm ulcerative lesion extending from the duodenal bulb to the descending portion, and biopsy confirmed poorly differentiated adenocarcinoma. Abdominal contrast-enhanced CT scan showed an hypovascular tumor in the pancreatic head with suspected invasion into the duodenum, along with enlarged #8 lymph node. PET-CT revealed abnormal uptake in the pancreatic head and #8 lymph node. She underwent robotic pancreaticoduodenectomy for a diagnosis of pancreatic head cancer with lymph node metastasis. Histopathological examination revealed proliferation of atypical cells in acinar, trabecular, ribbon-like anastomosing, and tubular structures. Immunohistochemistry showed positivity for Bcl10(60%), INSM1(20%), Ki-67 index of 45%, and coexistence of invasive ductal adenocarcinoma(20%). Based on these findings, the tumor was diagnosed as predominantly acinar cell carcinoma with invasive ductal adenocarcinoma and neuroendocrine tumor. Lymph node metastasis was positive showing Bcl10-positive acinar cell carcinoma. Four months postoperatively, recurrence was detected in the para-aortic lymph nodes, confirmed by biopsy to be acinar cell carcinoma. Chemotherapy was initiated but discontinued due to tumor progression leading to best supportive care.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[A Case of Pancreatic Acinar Cell Carcinoma with Invasive Ductal Carcinoma and Neuroendocrine Tumor].
Gan To Kagaku Ryoho
February 2025
Dept. of Surgery, Kansai Rosai Hospital.
A 50-year-old female presented with abdominal pain. Upper gastrointestinal endoscopy revealed a 30 mm ulcerative lesion extending from the duodenal bulb to the descending portion, and biopsy confirmed poorly differentiated adenocarcinoma. Abdominal contrast-enhanced CT scan showed an hypovascular tumor in the pancreatic head with suspected invasion into the duodenum, along with enlarged #8 lymph node.
View Article and Find Full Text PDFInflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition.
Cells
February 2025
Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand the bacterial microbiota changes accompanying PDAC promotion and progression stimulated by inflammation and fecal microbiota transplantation (FMT), we investigated stool and pancreatic microbiota by 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions of KrasG12D, and age- and sex-matched control mice that were exposed to inflammatory stimuli and fecal microbiota obtained from mice with PDAC. Time- and inflammatory-dependent stool and pancreatic bacterial composition alterations and stool alpha microbiota diversity reduction were observed only in mice with a Kras mutation that developed advanced pancreatic changes.
View Article and Find Full Text PDFHypoxia contributes to the early stage progression of necrotizing sialometaplasia.
Am J Pathol
March 2025
Section of Pathology, Department of Morphological Biology, Division of Biomedical Sciences, Fukuoka Dental College, Fukuoka, Japan.
Necrotizing sialometaplasia (NSM) is a non-neoplastic lesion listed in the WHO classification of Head and Neck Tumours. In early NSM lesion, there is infarction and necrosis of the acinar cells and squamous metaplasia of the salivary ducts occurs as the lesion matures. Differentiation from squamous cell carcinoma and other malignancies is sometimes required clinically and histopathologically.
View Article and Find Full Text PDFRobot-assisted corpo-caudal pancreatectomy and splenectomy for pancreatic acinar cell carcinoma: a case report.
J Surg Case Rep
March 2025
National Oncology Institute SOLCA Guayaquil, Department of Digestive Surgery, Guayaquil 090505, Ecuador.
Acinar cell carcinoma of the pancreas (ACCP) is an exceptionally rare malignancy, accounting for <1% of all exocrine pancreatic tumors. This case report describes a 78-year-old male presenting with abdominal pain, weight loss, and anorexia, diagnosed with a tumor in the pancreatic body through imaging and biopsy. The patient underwent a robot-assisted corpo-caudal pancreatectomy and splenectomy using the Da Vinci system.
View Article and Find Full Text PDFAcute pancreatitis caused by oral contraceptives.
Intern Emerg Med
March 2025
The Second Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Acute pancreatitis manifests as an inflammatory condition, starting with the acinar cells in the pancreas and gradually escalating to widespread inflammation. Hypertriglyceridemia ranks as the third leading reason for acute pancreatitis, following gallstones and alcohol use, making up 2-14% of instances [1]. Numerous research findings indicate that acute pancreatitis triggered by hypertriglyceridemia (HTG-AP, hypertriglyceridemic acute pancreatitis) may lead to increased death rates compared to other acute pancreatitis causes hypertriglyceridemia, characterized by fasting serum triglycerides exceeding (150mg/dL; 1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!